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. 2017 Jul 21;7(1):6097.
doi: 10.1038/s41598-017-06514-3.

Plasma dipeptidyl-peptidase-4 activity is associated with left ventricular systolic function in patients with ST-segment elevation myocardial infarction

Jing Wei Li  1   2 , Yun Dai Chen  3 , Yu Qi Liu  1 , Jin Da Wang  1 , Wei Ren Chen  1 , Ying Qian Zhang  1 , Qiang Ma  1
Affiliations

Plasma dipeptidyl-peptidase-4 activity is associated with left ventricular systolic function in patients with ST-segment elevation myocardial infarction

Jing Wei Li et al. Sci Rep. .

Abstract

Plasma dipeptidyl-peptidase-4 activity (DPP4a) is inversely associated with left ventricular function in patients with heart failure (HF) or diabetes. However, the association between DPP4a and left ventricular function in ST-segment elevation myocardial infarction (STEMI) patients has not been reported. We studied this association in 584 consecutive STEMI patients at a tertiary referral center from July 2014 to October 2015. DPP4a and plasma N-terminal prohormone of B-type natriuretic peptide (NT-proBNP) levels were quantified by enzymatic assays. The median serum NT-proBNP levels were highest in patients of the lowest tertile (T1) of DPP4a compared with that of the highest tertile (T3) (p = 0.028). The STEMI patients in T1 exhibited lower left ventricular systolic function (T1 vs. T3: left ventricular ejection fraction (LVEF): 50.13 ± 9.12 vs. 52.85 ± 6.82%, p = 0.001). Multivariate logistic-regression analyses (adjusted for confounding variables) showed that a 1 U/L increase in DPP4a was associated with a decreased incidence of left ventricular systolic dysfunction (LVSD) (adjusted odds ratio: 0.90; 95% CI: 0.87-0.94; p < 0.01). In conclusion, low DPP4a is independently associated with LVSD in STEMI patients, which suggests that DPP4 may be involved in the mechanisms of LVSD in STEMI patients.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Peak NT-proBNP according to plasma DPP4 activity tertiles in STEMI patients. Values represent as median with interquartile range. Box plots show the 10th and 90th (vertical lines), 25th and 75th (boxes) and 50th (horizontal line).
Figure 2
Figure 2
Distribution of echocardiographic parameters assessing left ventricular diastolic and systolic function of STEMI patients according to plasma DPP4 activity tertiles. Bar graphs show the mean ± SD for E/A ratio (A), subendocardial fractional shortening (FS) (B), left ventricular (LV) ejection fraction (LVEF) (C) and LV stroke work corrected by LV end-diastolic volume (LVEDV) (panel D). E, maximum early transmitral velocity in diastole; A, maximum late transmitral velocity in diastole.
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