Understanding the Genomic Ultraconservations: T-UCRs and Cancer

doi:10.1016/bs.ircmb.2017.04.004

Review

. 2017:333:159-172.

doi: 10.1016/bs.ircmb.2017.04.004. Epub 2017 Jun 7.

Understanding the Genomic Ultraconservations: T-UCRs and Cancer

Linda Fabris¹, George A Calin²

Affiliations

¹ The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
² The University of Texas MD Anderson Cancer Center, Houston, TX, United States; Center for RNA Interference and Non-Coding RNAs, The University of Texas MD Anderson Cancer Center, Houston, TX, United States. Electronic address: gcalin@mdanderson.org.

PMID: 28729024
DOI: 10.1016/bs.ircmb.2017.04.004

Review

Understanding the Genomic Ultraconservations: T-UCRs and Cancer

Linda Fabris et al. Int Rev Cell Mol Biol. 2017.

. 2017:333:159-172.

doi: 10.1016/bs.ircmb.2017.04.004. Epub 2017 Jun 7.

Authors

Linda Fabris¹, George A Calin²

Affiliations

¹ The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
² The University of Texas MD Anderson Cancer Center, Houston, TX, United States; Center for RNA Interference and Non-Coding RNAs, The University of Texas MD Anderson Cancer Center, Houston, TX, United States. Electronic address: gcalin@mdanderson.org.

PMID: 28729024
DOI: 10.1016/bs.ircmb.2017.04.004

Abstract

Transcribed ultraconserved regions (T-UCRs) are genomic regions conserved across large evolutionary distances, which encode for noncoding RNAs that serve as regulators of gene expression. Although T-UCRs have been linked to multiple aspects of mammalian gene regulation, the roles of their extreme evolutionary conservation remain largely unexplained. Growing body of literature is now focusing on T-UCRs as potential cancer biomarkers or as new drug targets. Here we present an overview of the discoveries so far published about the role of T-UCR in cancer and disease.

Keywords: Cancer; Noncoding RNA; T-UCR; Transcribed ultraconserved region.

PubMed Disclaimer

Cited by

Analysis of the circRNA and T-UCR populations identifies convergent pathways in mouse and human models of Rett syndrome.
Siqueira E, Obiols-Guardia A, Jorge-Torres OC, Oliveira-Mateos C, Soler M, Ramesh-Kumar D, Setién F, van Rossum D, Pascual-Alonso A, Xiol C, Ivan C, Shimizu M, Armstrong J, Calin GA, Pasterkamp RJ, Esteller M, Guil S. Siqueira E, et al. Mol Ther Nucleic Acids. 2021 Dec 22;27:621-644. doi: 10.1016/j.omtn.2021.12.030. eCollection 2022 Mar 8. Mol Ther Nucleic Acids. 2021. PMID: 35036070 Free PMC article.
A first comprehensive analysis of Transcribed Ultra Conserved Regions uncovers important regulatory functions of novel non-coding transcripts in gliomas.
Gibert MK Jr, Zhang Y, Saha S, Marcinkiewicz P, Dube C, Hudson K, Sun Y, Bednarek S, Chagari B, Sarkar A, Roig-Laboy C, Neace N, Saoud K, Setiady I, Hanif F, Schiff D, Kumar P, Kefas B, Hafner M, Abounader R. Gibert MK Jr, et al. Res Sq [Preprint]. 2024 Apr 18:rs.3.rs-4164642. doi: 10.21203/rs.3.rs-4164642/v1. Res Sq. 2024. PMID: 38699302 Free PMC article. Preprint.
Up-regulation of FOXN3-AS1 in invasive ductal carcinoma of breast cancer patients.
Molaei Ramshe S, Ghaedi H, Omrani MD, Geranpayeh L, Alipour B, Ghafouri-Fard S. Molaei Ramshe S, et al. Heliyon. 2021 Oct 14;7(10):e08179. doi: 10.1016/j.heliyon.2021.e08179. eCollection 2021 Oct. Heliyon. 2021. PMID: 34703931 Free PMC article.
LncRNAs and Available Databases.
Napoli S. Napoli S. Methods Mol Biol. 2021;2348:3-26. doi: 10.1007/978-1-0716-1581-2_1. Methods Mol Biol. 2021. PMID: 34160796 Review.
Transcribed Ultraconserved Regions in Cancer.
Gibert MK Jr, Sarkar A, Chagari B, Roig-Laboy C, Saha S, Bednarek S, Kefas B, Hanif F, Hudson K, Dube C, Zhang Y, Abounader R. Gibert MK Jr, et al. Cells. 2022 May 19;11(10):1684. doi: 10.3390/cells11101684. Cells. 2022. PMID: 35626721 Free PMC article. Review.

See all "Cited by" articles

Publication types

Actions
Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Understanding the Genomic Ultraconservations: T-UCRs and Cancer

Affiliations

Understanding the Genomic Ultraconservations: T-UCRs and Cancer

Authors

Affiliations

Abstract

Similar articles

Cited by

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources