Mesenchymal Stem/Progenitor Cells Derived from Articular Cartilage, Synovial Membrane and Synovial Fluid for Cartilage Regeneration: Current Status and Future Perspectives

doi:10.1007/s12015-017-9753-1

Review

. 2017 Oct;13(5):575-586.

doi: 10.1007/s12015-017-9753-1.

Mesenchymal Stem/Progenitor Cells Derived from Articular Cartilage, Synovial Membrane and Synovial Fluid for Cartilage Regeneration: Current Status and Future Perspectives

Yi-Zhou Huang¹, Hui-Qi Xie¹, Antonietta Silini², Ornella Parolini^{2

3}, Yi Zhang¹, Li Deng⁴, Yong-Can Huang^{5

6

7

8}

Affiliations

¹ Laboratory of Stem Cell and Tissue Engineering, West China Hospital, Sichuan University, Chengdu, China.
² Centro di Ricerca E. Menni, Fondazione Poliambulanza-Istituto Ospedaliero, Brescia, Italy.
³ Istituto di Anatomia Umana e Biologia Cellulare, Università Cattolica del Sacro Cuore Facoltà di Medicina e Chirurgia, Rome, Italy.
⁴ Laboratory of Stem Cell and Tissue Engineering, West China Hospital, Sichuan University, Chengdu, China. dengli2000@gmail.com.
⁵ Shenzhen Engineering Laboratory of Orthopaedic Regenerative Technologies, Orthopaedic Research Center, Peking University Shenzhen Hospital, Shenzhen, China. y.c.huang@connect.hku.hk.
⁶ Shenzhen Key Laboratory of Spine Surgery, Department of Spine Surgery, Peking University Shenzhen Hospital, Shenzhen, China. y.c.huang@connect.hku.hk.
⁷ Department of Orthopaedics and Traumatology, The University of Hong Kong, Hong Kong, SAR, China. y.c.huang@connect.hku.hk.
⁸ Beijing Key Laboratory for Genetic Research of Bone and Joint Disease, Central Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China. y.c.huang@connect.hku.hk.

PMID: 28721683
DOI: 10.1007/s12015-017-9753-1

Review

Mesenchymal Stem/Progenitor Cells Derived from Articular Cartilage, Synovial Membrane and Synovial Fluid for Cartilage Regeneration: Current Status and Future Perspectives

Yi-Zhou Huang et al. Stem Cell Rev Rep. 2017 Oct.

. 2017 Oct;13(5):575-586.

doi: 10.1007/s12015-017-9753-1.

Authors

Yi-Zhou Huang¹, Hui-Qi Xie¹, Antonietta Silini², Ornella Parolini^{2

3}, Yi Zhang¹, Li Deng⁴, Yong-Can Huang^{5

6

7

8}

Affiliations

¹ Laboratory of Stem Cell and Tissue Engineering, West China Hospital, Sichuan University, Chengdu, China.
² Centro di Ricerca E. Menni, Fondazione Poliambulanza-Istituto Ospedaliero, Brescia, Italy.
³ Istituto di Anatomia Umana e Biologia Cellulare, Università Cattolica del Sacro Cuore Facoltà di Medicina e Chirurgia, Rome, Italy.
⁴ Laboratory of Stem Cell and Tissue Engineering, West China Hospital, Sichuan University, Chengdu, China. dengli2000@gmail.com.
⁵ Shenzhen Engineering Laboratory of Orthopaedic Regenerative Technologies, Orthopaedic Research Center, Peking University Shenzhen Hospital, Shenzhen, China. y.c.huang@connect.hku.hk.
⁶ Shenzhen Key Laboratory of Spine Surgery, Department of Spine Surgery, Peking University Shenzhen Hospital, Shenzhen, China. y.c.huang@connect.hku.hk.
⁷ Department of Orthopaedics and Traumatology, The University of Hong Kong, Hong Kong, SAR, China. y.c.huang@connect.hku.hk.
⁸ Beijing Key Laboratory for Genetic Research of Bone and Joint Disease, Central Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China. y.c.huang@connect.hku.hk.

PMID: 28721683
DOI: 10.1007/s12015-017-9753-1

Abstract

Large articular cartilage defects remain an immense challenge in the field of regenerative medicine because of their poor intrinsic repair capacity. Currently, the available medical interventions can relieve clinical symptoms to some extent, but fail to repair the cartilaginous injuries with authentic hyaline cartilage. There has been a surge of interest in developing cell-based therapies, focused particularly on the use of mesenchymal stem/progenitor cells with or without scaffolds. Mesenchymal stem/progenitor cells are promising graft cells for tissue regeneration, but the most suitable source of cells for cartilage repair remains controversial. The tissue origin of mesenchymal stem/progenitor cells notably influences the biological properties and therapeutic potential. It is well known that mesenchymal stem/progenitor cells derived from synovial joint tissues exhibit superior chondrogenic ability compared with those derived from non-joint tissues; thus, these cell populations are considered ideal sources for cartilage regeneration. In addition to the progress in research and promising preclinical results, many important research questions must be answered before widespread success in cartilage regeneration is achieved. This review outlines the biology of stem/progenitor cells derived from the articular cartilage, the synovial membrane, and the synovial fluid, including their tissue distribution, function and biological characteristics. Furthermore, preclinical and clinical trials focusing on their applications for cartilage regeneration are summarized, and future research perspectives are discussed.

Keywords: Articular cartilage; Mesenchymal stem cells; Regenerative medicine; Synovial fluid; Synovial joint; Synovial membrane; progenitors.

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[1] Connect Tissue Res. 2007;48(3):132-40 - PubMed

[2] Connect Tissue Res. 2007;48(3):132-40 - PubMed

[3] Exp Cell Res. 2013 Nov 1;319(18):2856-65 - PubMed

[4] Exp Cell Res. 2013 Nov 1;319(18):2856-65 - PubMed

[5] Arthritis Rheum. 2006 Oct;54(10):3254-66 - PubMed

[6] Arthritis Rheum. 2006 Oct;54(10):3254-66 - PubMed

[7] Eur Cell Mater. 2016 May 27;31:407-24 - PubMed

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[9] Asian Pac J Trop Med. 2015 Sep;8(9):739-46 - PubMed

[10] Asian Pac J Trop Med. 2015 Sep;8(9):739-46 - PubMed

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Mesenchymal Stem/Progenitor Cells Derived from Articular Cartilage, Synovial Membrane and Synovial Fluid for Cartilage Regeneration: Current Status and Future Perspectives

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Mesenchymal Stem/Progenitor Cells Derived from Articular Cartilage, Synovial Membrane and Synovial Fluid for Cartilage Regeneration: Current Status and Future Perspectives

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