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Review
. 2017 Feb;3(2):73-75.
doi: 10.1016/j.trecan.2016.11.010. Epub 2016 Dec 23.

Cancer - An Insurgency of Clones

David Gisselsson  1 , Robert Egnell  2
Affiliations
Review

Cancer - An Insurgency of Clones

David Gisselsson et al. Trends Cancer. 2017 Feb.

Abstract

Oncological therapy resembles a military force that eliminates the central power of a country (dominant clone of a cancer) to create a vacuum where insurgents (subclones) thrive and instigate rebellion (relapse). We suggest that military counterinsurgency doctrine can inspire a discussion of cancer that uniquely embraces both cancer cell evolution and tumour microenvironment.

Keywords: cancer; counterinsurgency; evolution; microenvironment.

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