Dermatologic Manifestations of Chronic Hepatitis C Infection

doi:10.1016/j.cld.2017.03.010

Review

. 2017 Aug;21(3):555-564.

doi: 10.1016/j.cld.2017.03.010. Epub 2017 Apr 25.

Dermatologic Manifestations of Chronic Hepatitis C Infection

Mehmet Sayiner¹, Pegah Golabi², Freba Farhat³, Zobair M Younossi⁴

Affiliations

¹ Betty and Guy Beatty Center for Integrated Research, Inova Health System, Inova Fairfax Hospital, Claude Moore Health Education and Research Building, 3rd Floor, 3300 Gallows Road, Falls Church, VA 22042, USA; Department of Medicine, Center for Liver Disease, Inova Fairfax Hospital, Claude Moore Health Education and Research Building, 3rd Floor, 3300 Gallows Road, Falls Church, VA 22042, USA.
² Betty and Guy Beatty Center for Integrated Research, Inova Health System, Inova Fairfax Hospital, Claude Moore Health Education and Research Building, 3rd Floor, 3300 Gallows Road, Falls Church, VA 22042, USA.
³ Department of Medicine, Center for Liver Disease, Inova Fairfax Hospital, Claude Moore Health Education and Research Building, 3rd Floor, 3300 Gallows Road, Falls Church, VA 22042, USA.
⁴ Betty and Guy Beatty Center for Integrated Research, Inova Health System, Inova Fairfax Hospital, Claude Moore Health Education and Research Building, 3rd Floor, 3300 Gallows Road, Falls Church, VA 22042, USA; Department of Medicine, Center for Liver Disease, Inova Fairfax Hospital, Claude Moore Health Education and Research Building, 3rd Floor, 3300 Gallows Road, Falls Church, VA 22042, USA. Electronic address: Zobair.Younossi@inova.org.

PMID: 28689593
DOI: 10.1016/j.cld.2017.03.010

Review

Dermatologic Manifestations of Chronic Hepatitis C Infection

Mehmet Sayiner et al. Clin Liver Dis. 2017 Aug.

. 2017 Aug;21(3):555-564.

doi: 10.1016/j.cld.2017.03.010. Epub 2017 Apr 25.

Authors

Mehmet Sayiner¹, Pegah Golabi², Freba Farhat³, Zobair M Younossi⁴

Affiliations

¹ Betty and Guy Beatty Center for Integrated Research, Inova Health System, Inova Fairfax Hospital, Claude Moore Health Education and Research Building, 3rd Floor, 3300 Gallows Road, Falls Church, VA 22042, USA; Department of Medicine, Center for Liver Disease, Inova Fairfax Hospital, Claude Moore Health Education and Research Building, 3rd Floor, 3300 Gallows Road, Falls Church, VA 22042, USA.
² Betty and Guy Beatty Center for Integrated Research, Inova Health System, Inova Fairfax Hospital, Claude Moore Health Education and Research Building, 3rd Floor, 3300 Gallows Road, Falls Church, VA 22042, USA.
³ Department of Medicine, Center for Liver Disease, Inova Fairfax Hospital, Claude Moore Health Education and Research Building, 3rd Floor, 3300 Gallows Road, Falls Church, VA 22042, USA.
⁴ Betty and Guy Beatty Center for Integrated Research, Inova Health System, Inova Fairfax Hospital, Claude Moore Health Education and Research Building, 3rd Floor, 3300 Gallows Road, Falls Church, VA 22042, USA; Department of Medicine, Center for Liver Disease, Inova Fairfax Hospital, Claude Moore Health Education and Research Building, 3rd Floor, 3300 Gallows Road, Falls Church, VA 22042, USA. Electronic address: Zobair.Younossi@inova.org.

PMID: 28689593
DOI: 10.1016/j.cld.2017.03.010

Abstract

Chronic hepatitis C virus (HCV) infection is associated with various extrahepatic manifestations, including dermatologic involvement mostly caused by immune complexes. Mixed cryoglobulinemia has a strong relationship with HCV with 95% of these patients being infected with HCV. Lichen planus is a disease of the squamous epithelium and may affect any part of the skin, with 4% to 24% of patients with lichen planus reported to have chronic HCV infection. Porphyria cutanea tarda is the most common form of porphyria, and it is thought that HCV interferes with iron stores, which can promote porphyria cutanea tarda. Finally, necrolytic acral erythema is a rare, psoriasis-like disease closely associated with HCV.

Keywords: Cryoglobulinemia; Dermatologic manifestation; Extrahepatic manifestation; Hepatitis C; Lichen planus; Porphyria.

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Dermatologic Manifestations of Chronic Hepatitis C Infection

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Dermatologic Manifestations of Chronic Hepatitis C Infection

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