Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Jun;46(4):861-871.
doi: 10.1080/21691401.2017.1345930. Epub 2017 Jul 6.

Indigofera tinctoria leaf extract mediated green synthesis of silver and gold nanoparticles and assessment of their anticancer, antimicrobial, antioxidant and catalytic properties

Remya Vijayan  1 , Siby Joseph  1 , Beena Mathew  1
Affiliations
Free article

Indigofera tinctoria leaf extract mediated green synthesis of silver and gold nanoparticles and assessment of their anticancer, antimicrobial, antioxidant and catalytic properties

Remya Vijayan et al. Artif Cells Nanomed Biotechnol. 2018 Jun.
Free article

Abstract

This study reports the synthesis of noble metal nanoparticles, namely silver and gold from their respective salt by leaf extract of a medicinal plant Indigofera tinctoria. This leaf extract plays a dual role as stabilizing and reducing agent for the formation of nanoparticles. The synthesized silver and gold nanoparticles were characterized by UV-vis. spectroscopy, FTIR spectroscopy, XRD, TEM, EDX and AFM analysis. All these techniques confirm the formation of crystalline nanoparticles. The cytotoxic effect of I. tinctoria leaf extract and the nanoparticles were studied on lung cancer cell line A549. It was shown that the cell viability decreases with increasing concentration and nanoparticles has more toxic effect on cancer cell than the pure leaf extract. IC50 value of I. tinctoria leaf extract, AuNP and AgNP respectively, are 71.92 ± 0.76 μg/ml, 59.33 ± 0.57 μg/ml and 56.62 ± 0.86 μg/ml. Antimicrobial activities were tested against both bacterial and fungal strains by agar well diffusion method. The synthesized nanoparticles show high antimicrobial activities towards all tested microbial strains with varying degree. The antioxidant activities of synthesized nanoparticles were analysed by using DPPH method and found that nanoparticles show higher antioxidant activities than the leaf extract. Outstanding catalytic activities of nanoparticles were demonstrated by employing the reduction reactions of o/p-niroanilines by NaBH4.

Keywords: Indigofera tinctoria; anticancer; antimicrobial; antioxidant; catalysis; green synthesis.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

MeSH terms

LinkOut - more resources