Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Oct;37(10):1619-1628.
doi: 10.1007/s00296-017-3763-9. Epub 2017 Jul 5.

A systematic review of the barriers affecting medication adherence in patients with rheumatic diseases

Hendra Goh  1 , Yu Heng Kwan  2   3   4 , Yi Seah  5 , Lian Leng Low  6 , Warren Fong  7   8   9 , Julian Thumboo  10   7   8
Affiliations
Review

A systematic review of the barriers affecting medication adherence in patients with rheumatic diseases

Hendra Goh et al. Rheumatol Int. 2017 Oct.

Abstract

Medication adherence is a crucial part in the management of rheumatic diseases, especially with many such patients requiring long-term medications. In this paper, we aim to systematically review the literature for the factors associated with medication adherence in the rheumatic patient population. We carried out a systematic literature search using PubMed®, PsychInfo® and Embase ® with relevant keywords and employed the PRISMA® criteria. We included English peer-reviewed articles that studied the factors affecting medication adherence in patients with rheumatic diseases, which were assessed by two independent reviewers. Hand searches were conducted and relevant factors were extracted and classified using the World Health Organization (WHO)'s five dimensions of medication adherence. A simple diagram was drawn to summarise the factors extracted. 1977 articles were identified and reviewed and 90 articles were found to be relevant. A total of 17 factors and 38 sub-factors were identified and categorized based on the WHO's five dimensions of medication adherence. A hand model for medication adherence was developed to succinctly summarise these dimension to remind clinicians the importance of medication adherence in daily practice. We conducted a systematic review on the various factors including patient, therapy, condition, health system and socioeconomic-related factors that affected medication adherence in rheumatic patients. We found 17 factors and 38 sub-factors that affected medication adherence in this population. This systematic review can facilitate future focused research in unexplored dimensions.

Keywords: Adherence; Compliance; Factors; Rheumatology; Systematic review.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Appl Nurs Res. 2016 May;30:176-83 - PubMed
    1. Rheumatology (Oxford). 2015 Oct;54(10 ):1780-91 - PubMed
    1. Am J Med Sci. 2010 Oct;340(4):282-90 - PubMed
    1. Patient Prefer Adherence. 2016 May 19;10:863-70 - PubMed
    1. Arthritis Rheum. 2010 Jan;62(1):22-32 - PubMed

MeSH terms

Substances

LinkOut - more resources