Osteomacs and Bone Regeneration

doi:10.1007/s11914-017-0384-x

Review

. 2017 Aug;15(4):385-395.

doi: 10.1007/s11914-017-0384-x.

Osteomacs and Bone Regeneration

Lena Batoon¹, Susan Marie Millard¹, Liza Jane Raggatt^{1

2}, Allison Robyn Pettit^{3

4}

Affiliations

¹ Bones and Immunology Laboratory, Cancer Biology and Care Program, Mater Research Institute - The University of Queensland, Translational Research Institute, 37 Kent Street, Woolloongabba, QLD, 4102, Australia.
² Faculty of Medicine, The University of Queensland, Herston, QLD, 4092, Australia.
³ Bones and Immunology Laboratory, Cancer Biology and Care Program, Mater Research Institute - The University of Queensland, Translational Research Institute, 37 Kent Street, Woolloongabba, QLD, 4102, Australia. allison.pettit@mater.uq.edu.au.
⁴ Faculty of Medicine, The University of Queensland, Herston, QLD, 4092, Australia. allison.pettit@mater.uq.edu.au.

PMID: 28647885
DOI: 10.1007/s11914-017-0384-x

Review

Osteomacs and Bone Regeneration

Lena Batoon et al. Curr Osteoporos Rep. 2017 Aug.

. 2017 Aug;15(4):385-395.

doi: 10.1007/s11914-017-0384-x.

Authors

Lena Batoon¹, Susan Marie Millard¹, Liza Jane Raggatt^{1

2}, Allison Robyn Pettit^{3

4}

Affiliations

¹ Bones and Immunology Laboratory, Cancer Biology and Care Program, Mater Research Institute - The University of Queensland, Translational Research Institute, 37 Kent Street, Woolloongabba, QLD, 4102, Australia.
² Faculty of Medicine, The University of Queensland, Herston, QLD, 4092, Australia.
³ Bones and Immunology Laboratory, Cancer Biology and Care Program, Mater Research Institute - The University of Queensland, Translational Research Institute, 37 Kent Street, Woolloongabba, QLD, 4102, Australia. allison.pettit@mater.uq.edu.au.
⁴ Faculty of Medicine, The University of Queensland, Herston, QLD, 4092, Australia. allison.pettit@mater.uq.edu.au.

PMID: 28647885
DOI: 10.1007/s11914-017-0384-x

Abstract

Purpose of review: Mounting evidence supporting the critical contribution of macrophages, in particular osteal macrophages, to bone regeneration is reviewed. We specifically examine the potential role of macrophages in the basic multicellular units coordinating lifelong bone regeneration via remodelling and bone regeneration in response to injury. We review and discuss the distinctions between macrophage and osteoclast contributions to bone homeostasis, particularly the dichotomous role of the colony-stimulating factor 1-colony-stimulating factor 1 receptor axis.

Recent findings: The impact of inflammation associated with aging and other hallmarks of aging, including senescence, on macrophage function is addressed in the context of osteoporosis and delayed fracture repair. Resident macrophages versus recruited macrophage contributions to fracture healing are also discussed. We identify some of the remaining knowledge gaps that will need to be closed in order to maximise benefits from therapeutically modulating or mimicking the function of macrophages to improve bone health and regeneration over a lifetime.

Keywords: Bone regeneration; Fracture repair; Inflammaging; Macrophages; Osteoporosis; Senescence.

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[1] Arthritis Rheum. 2002 Mar;46(3):663-74 - PubMed

[2] Arthritis Rheum. 2002 Mar;46(3):663-74 - PubMed

[3] J Leukoc Biol. 2002 Oct;72(4):621-7 - PubMed

[4] J Leukoc Biol. 2002 Oct;72(4):621-7 - PubMed

[5] Autoimmunity. 2008 Apr;41(3):218-23 - PubMed

[6] Autoimmunity. 2008 Apr;41(3):218-23 - PubMed

[7] J Immunol Methods. 2014 Jun;408:89-100 - PubMed

[8] J Immunol Methods. 2014 Jun;408:89-100 - PubMed

[9] Acta Biomater. 2017 Apr 15;53:13-28 - PubMed

[10] Acta Biomater. 2017 Apr 15;53:13-28 - PubMed

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Osteomacs and Bone Regeneration

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Osteomacs and Bone Regeneration

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