Recombinant Human Thrombopoietin Promotes Platelet Engraftment and Improves Prognosis of Patients with Myelodysplastic Syndromes and Aplastic Anemia after Allogeneic Hematopoietic Stem Cell Transplantation

doi:10.1016/j.bbmt.2017.06.010

. 2017 Oct;23(10):1678-1684.

doi: 10.1016/j.bbmt.2017.06.010. Epub 2017 Jun 19.

Recombinant Human Thrombopoietin Promotes Platelet Engraftment and Improves Prognosis of Patients with Myelodysplastic Syndromes and Aplastic Anemia after Allogeneic Hematopoietic Stem Cell Transplantation

Hong Wang¹, Man Huang², Ying Zhao², Jia-Qian Qi², Chun Chen², Ya-Qiong Tang², Hui-Ying Qiu³, Cheng-Cheng Fu³, Xiao-Wen Tang³, De-Pei Wu³, Chang-Geng Ruan⁴, Yue Han⁵

Affiliations

¹ Jiangsu Institute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, China; Institute of Blood and Marrow Transplantation, Suzhou, China; Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Suzhou, China.
² Jiangsu Institute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, China.
³ Jiangsu Institute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, China; Institute of Blood and Marrow Transplantation, Suzhou, China; Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Suzhou, China; Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China.
⁴ Jiangsu Institute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, China; Institute of Blood and Marrow Transplantation, Suzhou, China; Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Suzhou, China; Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China. Electronic address: ruanchanggeng@suda.edu.cn.
⁵ Jiangsu Institute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, China; Institute of Blood and Marrow Transplantation, Suzhou, China; Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Suzhou, China; Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China. Electronic address: hanyue@suda.edu.cn.

PMID: 28642072
DOI: 10.1016/j.bbmt.2017.06.010

Free article

Recombinant Human Thrombopoietin Promotes Platelet Engraftment and Improves Prognosis of Patients with Myelodysplastic Syndromes and Aplastic Anemia after Allogeneic Hematopoietic Stem Cell Transplantation

Hong Wang et al. Biol Blood Marrow Transplant. 2017 Oct.

Free article

. 2017 Oct;23(10):1678-1684.

doi: 10.1016/j.bbmt.2017.06.010. Epub 2017 Jun 19.

Authors

Hong Wang¹, Man Huang², Ying Zhao², Jia-Qian Qi², Chun Chen², Ya-Qiong Tang², Hui-Ying Qiu³, Cheng-Cheng Fu³, Xiao-Wen Tang³, De-Pei Wu³, Chang-Geng Ruan⁴, Yue Han⁵

Affiliations

¹ Jiangsu Institute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, China; Institute of Blood and Marrow Transplantation, Suzhou, China; Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Suzhou, China.
² Jiangsu Institute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, China.
³ Jiangsu Institute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, China; Institute of Blood and Marrow Transplantation, Suzhou, China; Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Suzhou, China; Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China.
⁴ Jiangsu Institute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, China; Institute of Blood and Marrow Transplantation, Suzhou, China; Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Suzhou, China; Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China. Electronic address: ruanchanggeng@suda.edu.cn.
⁵ Jiangsu Institute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, China; Institute of Blood and Marrow Transplantation, Suzhou, China; Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Suzhou, China; Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China. Electronic address: hanyue@suda.edu.cn.

PMID: 28642072
DOI: 10.1016/j.bbmt.2017.06.010

Abstract

Poor platelet graft function (PPGF) is a significant complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, no optimal treatment has been recommended. This study investigated aspects of platelet recovery after allo-HSCT, including prognostic value and the effect of recombinant human thrombopoietin (rhTPO). We retrospectively analyzed 275 patients who received allo-HSCT in our center. Of them, 135 (49.1%) patients had good platelet graft function (GPGF) and 140 (50.9%) had PPGF. The latter included 59 (21.5%) patients with primary PPGF and 81 (29.4%) with secondary PPGF. Multivariate analysis showed that male gender (P = .024), lower CD34⁺ cell count (P = .04), and no use of rhTPO (P <.001) were associated with PPGF. The 3-year overall survival rate of patients with PPGF (58%) was significantly less than that of patients with GPGF (82%; P <.001). We further analyzed the effect of rhTPO on prognosis of patients after allo-HSCT. Although no advantage was apparent when analyzing the entire cohort, for patients with myelodysplastic syndromes and aplastic anemia, rhTPO was associated with a significant survival advantage (P = .014).

Keywords: Platelet graft function; Prognosis; Recombinant human thrombopoietin; Stem cell transplantation.

PubMed Disclaimer

Cited by

Recombinant human thrombopoietin promotes platelet engraftment after umbilical cord blood transplantation.
Tang B, Huang L, Liu H, Cheng S, Song K, Zhang X, Yao W, Ning L, Wan X, Sun G, Wu Y, Cheng J, Long Q, Sun Z, Zhu X. Tang B, et al. Blood Adv. 2020 Aug 25;4(16):3829-3839. doi: 10.1182/bloodadvances.2020002257. Blood Adv. 2020. PMID: 32790845 Free PMC article. Clinical Trial.
Avatrombopag for the treatment of thrombocytopenia post hematopoietic stem-cell transplantation.
Zhou M, Qi J, Gu C, Wang H, Zhang Z, Wu D, Han Y. Zhou M, et al. Ther Adv Hematol. 2022 Sep 28;13:20406207221127532. doi: 10.1177/20406207221127532. eCollection 2022. Ther Adv Hematol. 2022. PMID: 36185780 Free PMC article.
[Clinical analysis of bronchiolitis obliterans syndrome after haplo- hematopoietic stem cell transplantation].
Zhuang J, Gu B, Ke P, Liu YJ, Wu XJ, Xue SL, Hu XH, He XF, Ma X, Wu DP. Zhuang J, et al. Zhonghua Xue Ye Xue Za Zhi. 2019 May 14;40(5):404-410. doi: 10.3760/cma.j.issn.0253-2727.2019.05.011. Zhonghua Xue Ye Xue Za Zhi. 2019. PMID: 31207706 Free PMC article. Chinese.
[Chinese expert consensus on the management of hemorrhagic complications after hematopoietic stem cell transplantation(2021)].
Chinese Society of Hematology, Chinese Medical Association. Chinese Society of Hematology, Chinese Medical Association. Zhonghua Xue Ye Xue Za Zhi. 2021 Apr 14;42(4):276-280. doi: 10.3760/cma.j.issn.0253-2727.2021.04.002. Zhonghua Xue Ye Xue Za Zhi. 2021. PMID: 33979970 Free PMC article. Chinese. No abstract available.
[Impact on platelet recovery of recombinant human thrombopoietin in severe aplastic anemia patients with allogeneic hematopoietic stem cell transplantation].
Song Y, Zhou F, Song NX, Liu XM, Yu Z, Xie LN, Song XC, Li X. Song Y, et al. Zhonghua Xue Ye Xue Za Zhi. 2018 Mar 14;39(3):207-211. doi: 10.3760/cma.j.issn.0253-2727.2018.03.007. Zhonghua Xue Ye Xue Za Zhi. 2018. PMID: 29562465 Free PMC article. Chinese.

See all "Cited by" articles

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions

LinkOut - more resources

Full Text Sources
- ClinicalKey
- Elsevier Science
Other Literature Sources
- scite Smart Citations
Medical
- MedlinePlus Health Information

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Recombinant Human Thrombopoietin Promotes Platelet Engraftment and Improves Prognosis of Patients with Myelodysplastic Syndromes and Aplastic Anemia after Allogeneic Hematopoietic Stem Cell Transplantation

Affiliations

Recombinant Human Thrombopoietin Promotes Platelet Engraftment and Improves Prognosis of Patients with Myelodysplastic Syndromes and Aplastic Anemia after Allogeneic Hematopoietic Stem Cell Transplantation

Authors

Affiliations

Abstract

Similar articles

Cited by

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Abstract

Similar articles

Cited by

MeSH terms

Substances

Related information

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical