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Review
. 2018 Apr;27(4):405-417.
doi: 10.1158/1055-9965.EPI-17-0169. Epub 2017 Jun 21.

Genome-Wide Association Studies of Cancer in Diverse Populations

Sungshim L Park  1 , Iona Cheng  2   3 , Christopher A Haiman  4
Affiliations
Review

Genome-Wide Association Studies of Cancer in Diverse Populations

Sungshim L Park et al. Cancer Epidemiol Biomarkers Prev. 2018 Apr.

Abstract

Genome-wide association studies (GWAS) of cancer have identified more than 700 risk loci, of which approximately 80% were first discovered in European ancestry populations, approximately 15% in East Asians, 3% in multiethnic scans, and less than 1% in African and Latin American populations. These percentages closely mirror the distribution of samples included in the discovery phase of cancer GWAS to date (84% European, 11% East Asian, 4% African, and 1% Latin American ancestry). GWAS in non-European ancestry populations have provided insight into ancestry-specific variation in cancer and have pointed to regions of susceptibility that are of particular importance in certain populations. Uncovering and characterizing cancer risk loci in diverse populations is critical for understanding underlying biological mechanisms and developing future genetic risk prediction models in non-European ancestry populations. New GWAS and continued collaborations will be required to eliminate population inequalities in the number of studies, sample sizes, and variant content on GWAS arrays, and to better align genetic research in cancer to the global distribution of race/ethnicity Cancer Epidemiol Biomarkers Prev; 27(4); 405-17. ©2018 AACRSee all articles in this CEBP Focus section, "Genome-Wide Association Studies in Cancer."

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Figures

Figure 1
Figure 1
The number of cancer cases included in the discovery stage of GWAS by ancestral population and cancer site. Shown are cancer sites with >100 cancer cases in a discovery stage.
Figure 2
Figure 2
The distribution of cancer cases in the discovery stage of GWAS of cancer by ancestral population (overall n ~478,000)
See this image and copyright information in PMC

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