An Unsettled Debate About the Potential Role of Infection in Pathogenesis of Atherosclerosis

doi:10.14740/jocmr3032w

Review

. 2017 Jul;9(7):547-554.

doi: 10.14740/jocmr3032w. Epub 2017 May 22.

An Unsettled Debate About the Potential Role of Infection in Pathogenesis of Atherosclerosis

Udip Dahal¹, Dikshya Sharma², Kumud Dahal³

Affiliations

¹ Department of Medicine, University of Utah, 50 N Medical Drive, Salt Lake City, UT, USA.
² Department of Internal Medicine, Staten Island University Hospital, 475 Seaview Avenue, Staten Island, NY, USA.
³ Department of Infectious Disease, University of Illinois College of Medicine at Peoria, 1 Illinoi Drive, Peoria, IL, USA.

PMID: 28611853
PMCID: PMC5458650
DOI: 10.14740/jocmr3032w

Review

An Unsettled Debate About the Potential Role of Infection in Pathogenesis of Atherosclerosis

Udip Dahal et al. J Clin Med Res. 2017 Jul.

. 2017 Jul;9(7):547-554.

doi: 10.14740/jocmr3032w. Epub 2017 May 22.

Authors

Udip Dahal¹, Dikshya Sharma², Kumud Dahal³

Affiliations

¹ Department of Medicine, University of Utah, 50 N Medical Drive, Salt Lake City, UT, USA.
² Department of Internal Medicine, Staten Island University Hospital, 475 Seaview Avenue, Staten Island, NY, USA.
³ Department of Infectious Disease, University of Illinois College of Medicine at Peoria, 1 Illinoi Drive, Peoria, IL, USA.

PMID: 28611853
PMCID: PMC5458650
DOI: 10.14740/jocmr3032w

Abstract

Association of infection with atherosclerosis is by no means new. Several sero-epidemiological and pathologic studies as well as animal models have shown a link between infection and atherosclerosis. Exciting discoveries in recent times related to role of inter-individual genetic variation in modulating inflammatory response to infection have reignited the enthusiasm in proving a causal link between infection and atherosclerosis. The purpose of this article was to review and analyze the available evidence linking infection with atherosclerosis.

Keywords: Antibiotics; Inflammatory; Multifactorial.

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References

1. Singh RB, Mengi SA, Xu YJ, Arneja AS, Dhalla NS. Pathogenesis of atherosclerosis: A multifactorial process. Exp Clin Cardiol. 2002;7(1):40–53. - PMC - PubMed
1. Fruchart JC, Nierman MC, Stroes ES, Kastelein JJ, Duriez P. New risk factors for atherosclerosis and patient risk assessment. Circulation. 2004;109(23 Suppl 1):III15–19. doi: 10.1161/01.cir.0000131513.33892.5b. - DOI - PubMed
1. Berry JD, Dyer A, Cai X, Garside DB, Ning H, Thomas A, Greenland P. et al. Lifetime risks of cardiovascular disease. N Engl J Med. 2012;366(4):321–329. doi: 10.1056/NEJMoa1012848. - DOI - PMC - PubMed
1. Berenson GS, Srinivasan SR, Bao W, Newman WP 3rd, Tracy RE, Wattigney WA. Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. The Bogalusa Heart Study. N Engl J Med. 1998;338(23):1650–1656. doi: 10.1056/NEJM199806043382302. - DOI - PubMed
1. Verschuren WM, Jacobs DR, Bloemberg BP, Kromhout D, Menotti A, Aravanis C, Blackburn H. et al. Serum total cholesterol and long-term coronary heart disease mortality in different cultures. Twenty-five-year follow-up of the seven countries study. JAMA. 1995;274(2):131–136. doi: 10.1001/jama.1995.03530020049031. - DOI - PubMed

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[1] Singh RB, Mengi SA, Xu YJ, Arneja AS, Dhalla NS. Pathogenesis of atherosclerosis: A multifactorial process. Exp Clin Cardiol. 2002;7(1):40–53. - PMC - PubMed

[2] Singh RB, Mengi SA, Xu YJ, Arneja AS, Dhalla NS. Pathogenesis of atherosclerosis: A multifactorial process. Exp Clin Cardiol. 2002;7(1):40–53. - PMC - PubMed

[3] Fruchart JC, Nierman MC, Stroes ES, Kastelein JJ, Duriez P. New risk factors for atherosclerosis and patient risk assessment. Circulation. 2004;109(23 Suppl 1):III15–19. doi: 10.1161/01.cir.0000131513.33892.5b. - DOI - PubMed

[4] Fruchart JC, Nierman MC, Stroes ES, Kastelein JJ, Duriez P. New risk factors for atherosclerosis and patient risk assessment. Circulation. 2004;109(23 Suppl 1):III15–19. doi: 10.1161/01.cir.0000131513.33892.5b. - DOI - PubMed

[5] Berry JD, Dyer A, Cai X, Garside DB, Ning H, Thomas A, Greenland P. et al. Lifetime risks of cardiovascular disease. N Engl J Med. 2012;366(4):321–329. doi: 10.1056/NEJMoa1012848. - DOI - PMC - PubMed

[6] Berry JD, Dyer A, Cai X, Garside DB, Ning H, Thomas A, Greenland P. et al. Lifetime risks of cardiovascular disease. N Engl J Med. 2012;366(4):321–329. doi: 10.1056/NEJMoa1012848. - DOI - PMC - PubMed

[7] Berenson GS, Srinivasan SR, Bao W, Newman WP 3rd, Tracy RE, Wattigney WA. Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. The Bogalusa Heart Study. N Engl J Med. 1998;338(23):1650–1656. doi: 10.1056/NEJM199806043382302. - DOI - PubMed

[8] Berenson GS, Srinivasan SR, Bao W, Newman WP 3rd, Tracy RE, Wattigney WA. Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. The Bogalusa Heart Study. N Engl J Med. 1998;338(23):1650–1656. doi: 10.1056/NEJM199806043382302. - DOI - PubMed

[9] Verschuren WM, Jacobs DR, Bloemberg BP, Kromhout D, Menotti A, Aravanis C, Blackburn H. et al. Serum total cholesterol and long-term coronary heart disease mortality in different cultures. Twenty-five-year follow-up of the seven countries study. JAMA. 1995;274(2):131–136. doi: 10.1001/jama.1995.03530020049031. - DOI - PubMed

[10] Verschuren WM, Jacobs DR, Bloemberg BP, Kromhout D, Menotti A, Aravanis C, Blackburn H. et al. Serum total cholesterol and long-term coronary heart disease mortality in different cultures. Twenty-five-year follow-up of the seven countries study. JAMA. 1995;274(2):131–136. doi: 10.1001/jama.1995.03530020049031. - DOI - PubMed

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An Unsettled Debate About the Potential Role of Infection in Pathogenesis of Atherosclerosis

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An Unsettled Debate About the Potential Role of Infection in Pathogenesis of Atherosclerosis

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