Targeting Plasma Cells with Proteasome Inhibitors: Principles from Primates

doi:10.1681/ASN.2017040443

Editorial

. 2017 Jul;28(7):1951-1953.

doi: 10.1681/ASN.2017040443. Epub 2017 Jun 7.

Targeting Plasma Cells with Proteasome Inhibitors: Principles from Primates

E Steve Woodle^{1

2}, Simon Tremblay^{3

2}, James Driscoll^{3

2}

Affiliations

¹ Division of Transplantation, Department of Surgery, and woodlees@ucmail.uc.edu.
² Division of Hematology and Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.
³ Division of Transplantation, Department of Surgery, and.

PMID: 28592425
PMCID: PMC5491302
DOI: 10.1681/ASN.2017040443

Editorial

Targeting Plasma Cells with Proteasome Inhibitors: Principles from Primates

E Steve Woodle et al. J Am Soc Nephrol. 2017 Jul.

. 2017 Jul;28(7):1951-1953.

doi: 10.1681/ASN.2017040443. Epub 2017 Jun 7.

Authors

E Steve Woodle^{1

2}, Simon Tremblay^{3

2}, James Driscoll^{3

2}

Affiliations

¹ Division of Transplantation, Department of Surgery, and woodlees@ucmail.uc.edu.
² Division of Hematology and Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.
³ Division of Transplantation, Department of Surgery, and.

PMID: 28592425
PMCID: PMC5491302
DOI: 10.1681/ASN.2017040443

No abstract available

Keywords: B cell; HLA antibody; desensitization; plasma cell; proteasome inhibitor.

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Humoral Compensation after Bortezomib Treatment of Allosensitized Recipients.
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References

1. Tarlinton DM, Hodgkin PD: Targeting plasma cells in autoimmune diseases. J Exp Med 199: 1451–1454, 2004 - PMC - PubMed
1. Neubert K, Meister S, Moser K, Weisel F, Maseda D, Amann K, Wiethe C, Winkler TH, Kalden JR, Manz RA, Voll RE: The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis. Nat Med 14: 748–755, 2008 - PubMed
1. Everly MJ, Everly JJ, Susskind B, Brailey P, Arend LJ, Alloway RR, Roy-Chaudhury P, Govil A, Mogilishetty G, Rike AH, Cardi M, Wadih G, Tevar A, Woodle ES: Bortezomib provides effective therapy for antibody- and cell-mediated acute rejection. Transplantation 86: 1754–1761, 2008 - PubMed
1. Bontscho J, Schreiber A, Manz RA, Schneider W, Luft FC, Kettritz R: Myeloperoxidase-specific plasma cell depletion by bortezomib protects from anti-neutrophil cytoplasmic autoantibodies-induced glomerulonephritis. J Am Soc Nephrol 22: 336–348, 2011 - PMC - PubMed
1. Gomez AM, Vrolix K, Martínez-Martínez P, Molenaar PC, Phernambucq M, van der Esch E, Duimel H, Verheyen F, Voll RE, Manz RA, De Baets MH, Losen M: Proteasome inhibition with bortezomib depletes plasma cells and autoantibodies in experimental autoimmune myasthenia gravis. J Immunol 186: 2503–2513, 2011 - PubMed

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[1] Tarlinton DM, Hodgkin PD: Targeting plasma cells in autoimmune diseases. J Exp Med 199: 1451–1454, 2004 - PMC - PubMed

[2] Tarlinton DM, Hodgkin PD: Targeting plasma cells in autoimmune diseases. J Exp Med 199: 1451–1454, 2004 - PMC - PubMed

[3] Neubert K, Meister S, Moser K, Weisel F, Maseda D, Amann K, Wiethe C, Winkler TH, Kalden JR, Manz RA, Voll RE: The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis. Nat Med 14: 748–755, 2008 - PubMed

[4] Neubert K, Meister S, Moser K, Weisel F, Maseda D, Amann K, Wiethe C, Winkler TH, Kalden JR, Manz RA, Voll RE: The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis. Nat Med 14: 748–755, 2008 - PubMed

[5] Everly MJ, Everly JJ, Susskind B, Brailey P, Arend LJ, Alloway RR, Roy-Chaudhury P, Govil A, Mogilishetty G, Rike AH, Cardi M, Wadih G, Tevar A, Woodle ES: Bortezomib provides effective therapy for antibody- and cell-mediated acute rejection. Transplantation 86: 1754–1761, 2008 - PubMed

[6] Everly MJ, Everly JJ, Susskind B, Brailey P, Arend LJ, Alloway RR, Roy-Chaudhury P, Govil A, Mogilishetty G, Rike AH, Cardi M, Wadih G, Tevar A, Woodle ES: Bortezomib provides effective therapy for antibody- and cell-mediated acute rejection. Transplantation 86: 1754–1761, 2008 - PubMed

[7] Bontscho J, Schreiber A, Manz RA, Schneider W, Luft FC, Kettritz R: Myeloperoxidase-specific plasma cell depletion by bortezomib protects from anti-neutrophil cytoplasmic autoantibodies-induced glomerulonephritis. J Am Soc Nephrol 22: 336–348, 2011 - PMC - PubMed

[8] Bontscho J, Schreiber A, Manz RA, Schneider W, Luft FC, Kettritz R: Myeloperoxidase-specific plasma cell depletion by bortezomib protects from anti-neutrophil cytoplasmic autoantibodies-induced glomerulonephritis. J Am Soc Nephrol 22: 336–348, 2011 - PMC - PubMed

[9] Gomez AM, Vrolix K, Martínez-Martínez P, Molenaar PC, Phernambucq M, van der Esch E, Duimel H, Verheyen F, Voll RE, Manz RA, De Baets MH, Losen M: Proteasome inhibition with bortezomib depletes plasma cells and autoantibodies in experimental autoimmune myasthenia gravis. J Immunol 186: 2503–2513, 2011 - PubMed

[10] Gomez AM, Vrolix K, Martínez-Martínez P, Molenaar PC, Phernambucq M, van der Esch E, Duimel H, Verheyen F, Voll RE, Manz RA, De Baets MH, Losen M: Proteasome inhibition with bortezomib depletes plasma cells and autoantibodies in experimental autoimmune myasthenia gravis. J Immunol 186: 2503–2513, 2011 - PubMed

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Targeting Plasma Cells with Proteasome Inhibitors: Principles from Primates

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