doi: 10.1016/s0140-6736(85)91037-2.
Prospective study of cancer in patients with hypogammaglobulinaemia
- PMID: 2857327
- DOI: 10.1016/s0140-6736(85)91037-2
Item in Clipboard
Prospective study of cancer in patients with hypogammaglobulinaemia
Lancet.
.
Abstract
Among 377 patients with primary hypogammaglobulinaemia, mainly common variable immunodeficiency (CVID), 316 patients survived the first 2 years after diagnosis and were the subject of a study of cancer incidence. Among the 220 patients with CVID, there was a 5-fold increase of cancer due mainly to large excesses of stomach cancer (47-fold) and lymphomas (30-fold). The excess of stomach cancer is probably related to the high frequency of achlorhydria in CVID. 3 of the 7 patients with stomach cancer and CVID survived for 5 years or longer.
Similar articles
-
Cancer risk among patients with IgA deficiency or common variable immunodeficiency and their relatives: a combined Danish and Swedish study.Clin Exp Immunol. 2002 Dec;130(3):495-500. doi: 10.1046/j.1365-2249.2002.02004.x. Clin Exp Immunol. 2002. PMID: 12452841 Free PMC article.
-
Primary hypogammaglobulinaemia: a survey of clinical manifestations and complications.Q J Med. 1993 Jan;86(1):31-42. Q J Med. 1993. PMID: 8438047
-
Comparison of pulmonary diseases in common variable immunodeficiency and X-linked agammaglobulinaemia.Respirology. 2010 Feb;15(2):289-95. doi: 10.1111/j.1440-1843.2009.01679.x. Epub 2009 Dec 27. Respirology. 2010. PMID: 20051045
-
[Cancer in Rwanda. Study of relative frequency].Bull Cancer. 1986;73(2):155-64. Bull Cancer. 1986. PMID: 3730635 French.
-
[Cancer in children: epidemiologic, diagnostic and therapeutic characteristics].Rev Prat. 2008 Mar 15;58(5):557-63. Rev Prat. 2008. PMID: 18524116 Review. French. No abstract available.
Cited by
-
Common variable immunodeficiency.Am J Rhinol Allergy. 2013 Jul-Aug;27(4):260-5. doi: 10.2500/ajra.2013.27.3899. Am J Rhinol Allergy. 2013. PMID: 23883805 Free PMC article.
-
IgA deficiency and risk of cancer: a population-based matched cohort study.J Clin Immunol. 2015 Feb;35(2):182-8. doi: 10.1007/s10875-014-0124-2. Epub 2015 Jan 15. J Clin Immunol. 2015. PMID: 25589342
-
Use of combination chemotherapy for treatment of granulomatous and lymphocytic interstitial lung disease (GLILD) in patients with common variable immunodeficiency (CVID).J Clin Immunol. 2013 Jan;33(1):30-9. doi: 10.1007/s10875-012-9755-3. Epub 2012 Aug 29. J Clin Immunol. 2013. PMID: 22930256 Free PMC article. Clinical Trial.
-
Acquired immunodeficiency, malabsorption and lymphoma.Postgrad Med J. 1990 Feb;66(772):122-4. doi: 10.1136/pgmj.66.772.122. Postgrad Med J. 1990. PMID: 2349181 Free PMC article.
-
Intestinal B cell defects in common variable immunodeficiency.Clin Exp Immunol. 1994 Feb;95(2):215-21. doi: 10.1111/j.1365-2249.1994.tb06513.x. Clin Exp Immunol. 1994. PMID: 8306494 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
