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Review
. 2017 May 31;19(6):581-588.
doi: 10.1038/ncb3524.

Multiscale force sensing in development

Nicoletta I Petridou  1 , Zoltán Spiró  1 , Carl-Philipp Heisenberg  1
Affiliations
Review

Multiscale force sensing in development

Nicoletta I Petridou et al. Nat Cell Biol. .

Abstract

The seminal observation that mechanical signals can elicit changes in biochemical signalling within cells, a process commonly termed mechanosensation and mechanotransduction, has revolutionized our understanding of the role of cell mechanics in various fundamental biological processes, such as cell motility, adhesion, proliferation and differentiation. In this Review, we will discuss how the interplay and feedback between mechanical and biochemical signals control tissue morphogenesis and cell fate specification in embryonic development.

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