Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Jul;34(7):119.
doi: 10.1007/s12032-017-0975-5. Epub 2017 May 19.

Advances in systemic therapy for metastatic breast cancer: future perspectives

S P Corona  1 , N Sobhani  1 , A Ianza  1 , G Roviello  1 , G Mustacchi  1 , M Bortul  1 , F Zanconati  1 , D Generali  2
Affiliations
Review

Advances in systemic therapy for metastatic breast cancer: future perspectives

S P Corona et al. Med Oncol. 2017 Jul.

Erratum in

Abstract

Breast cancer (BC) is the most common cancer in women worldwide. One in eight women will develop the disease in her lifetime. Notwithstanding the incredible progress made in this field, BC still represents the second most common cause of cancer-related death in women. Targeted drugs have revolutionised breast cancer treatment and improved the prognosis as well as the life expectancy of millions of women. However, the phenomenon of primary and secondary pharmacological resistance is becoming increasingly evident, limiting the efficacy of these agents and calling for a better in-depth knowledge and understanding of the biology as well as the biochemical crosstalk underlying the disease. The advent of laboratory technologies in the clinical setting such as the routine use of next generation sequencing has allowed identification of new genetic alterations as well as providing a precise picture of the molecular landscapes of each tumour. Consequently, new specific therapeutic approaches are becoming available to minimise or delay the occurrence of resistance. In this review, we analyse the latest research and news from the clinical development side for each BC subtype.

Keywords: BC; Cancer; Metastatic BC; Systemic.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Eur J Cancer. 2013 Dec;49(18):3763-72 - PubMed
    1. Clin Breast Cancer. 2013 Aug;13(4):223-32 - PubMed
    1. Lancet. 2007 Jan 6;369(9555):29-36 - PubMed
    1. Proc Natl Acad Sci U S A. 2009 May 19;106(20):8368-73 - PubMed
    1. Breast. 2013 Aug;22 Suppl 2:S12-8 - PubMed

MeSH terms