Mast Cells Are Crucial for Induction of Group 2 Innate Lymphoid Cells and Clearance of Helminth Infections
- PMID: 28514691
- DOI: 10.1016/j.immuni.2017.04.017
Mast Cells Are Crucial for Induction of Group 2 Innate Lymphoid Cells and Clearance of Helminth Infections
Abstract
Mast cells are important for eradication of intestinal nematodes; however, their precise mechanisms of action have remained elusive, especially in the early phase of infection. We found that Spi-B-deficient mice had increased numbers of mast cells and rapidly expelled the Heligmosomoides polygyrus (Hp) nematode. This was accompanied by induction of interleukin-13 (IL-13)-producing group 2 innate lymphoid cells (ILC2) and goblet cell hyperplasia. Immediately after Hp infection, mast cells were rapidly activated to produce IL-33 in response to ATP released from apoptotic intestinal epithelial cells. In vivo inhibition of the P2X7 ATP receptor rendered the Spi-B-deficient mice susceptible to Hp, concomitant with elimination of mast cell activation and IL-13-producing ILC2 induction. These results uncover a previously unknown role for mast cells in innate immunity in that activation of mast cells by ATP orchestrates the development of a protective type 2 immune response, in part by producing IL-33, which contributes to ILC2 activation.
Keywords: IL-33; ILC2; helminth infection; mast cells; mucosal immunology.
Copyright © 2017 Elsevier Inc. All rights reserved.
Comment in
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Only Two Can Tango: Mast Cells Displace Epithelial Cells to Dance with ILC2s.Immunity. 2017 May 16;46(5):766-768. doi: 10.1016/j.immuni.2017.04.020. Immunity. 2017. PMID: 28514681
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