Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Jun;46(2):311-325.
doi: 10.1016/j.gtc.2017.01.006.

Immunohistochemistry in the Diagnosis of Hepatocellular Carcinoma

Won-Tak Choi  1 , Sanjay Kakar  2
Affiliations
Review

Immunohistochemistry in the Diagnosis of Hepatocellular Carcinoma

Won-Tak Choi et al. Gastroenterol Clin North Am. 2017 Jun.

Abstract

Hepatocellular carcinoma (HCC) can be difficult to distinguish from its mimics, including metastatic tumor, benign hepatocellular lesion, and high-grade dysplastic nodule, especially when limited biopsy material is available. Hence, the judicious use of immunohistochemical stains is necessary to establish a correct diagnosis. This article describes advantages and disadvantages of immunohistochemical markers that are most commonly used to distinguish between these lesions. Diagnostic workup of malignant liver mass (HCC and its histologic variants vs metastatic tumor) as well as well-differentiated hepatocellular lesion (well-differentiated HCC vs focal nodular hyperplasia vs hepatocellular adenoma) is also discussed.

Keywords: Focal nodular hyperplasia; Hepatocellular adenoma; Hepatocellular carcinoma; Immunohistochemistry; Well-differentiated hepatocellular lesion.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

MeSH terms