The Neuroprotective Effects of Phenolic Acids: Molecular Mechanism of Action

doi:10.3390/nu9050477

Review

. 2017 May 10;9(5):477.

doi: 10.3390/nu9050477.

The Neuroprotective Effects of Phenolic Acids: Molecular Mechanism of Action

Dominik Szwajgier¹, Kamila Borowiec², Katarzyna Pustelniak³

Affiliations

¹ Department of Biotechnology, Human Nutrition and the Science of Food Commodities, University of Life Sciences in Lublin, Lublin 20704, Poland. dszwajgier@hotmail.com.
² Department of Biotechnology, Human Nutrition and the Science of Food Commodities, University of Life Sciences in Lublin, Lublin 20704, Poland. kam.borowiec@gmail.com.
³ Department of Biotechnology, Human Nutrition and the Science of Food Commodities, University of Life Sciences in Lublin, Lublin 20704, Poland. kasia.pustus@wp.pl.

PMID: 28489058
PMCID: PMC5452207
DOI: 10.3390/nu9050477

Review

The Neuroprotective Effects of Phenolic Acids: Molecular Mechanism of Action

Dominik Szwajgier et al. Nutrients. 2017.

. 2017 May 10;9(5):477.

doi: 10.3390/nu9050477.

Authors

Dominik Szwajgier¹, Kamila Borowiec², Katarzyna Pustelniak³

Affiliations

¹ Department of Biotechnology, Human Nutrition and the Science of Food Commodities, University of Life Sciences in Lublin, Lublin 20704, Poland. dszwajgier@hotmail.com.
² Department of Biotechnology, Human Nutrition and the Science of Food Commodities, University of Life Sciences in Lublin, Lublin 20704, Poland. kam.borowiec@gmail.com.
³ Department of Biotechnology, Human Nutrition and the Science of Food Commodities, University of Life Sciences in Lublin, Lublin 20704, Poland. kasia.pustus@wp.pl.

PMID: 28489058
PMCID: PMC5452207
DOI: 10.3390/nu9050477

Abstract

The neuroprotective role of phenolic acids from food has previously been reported by many authors. In this review, the role of phenolic acids in ameliorating depression, ischemia/reperfusion injury, neuroinflammation, apoptosis, glutamate-induced toxicity, epilepsy, imbalance after traumatic brain injury, hyperinsulinemia-induced memory impairment, hearing and vision disturbances, Parkinson's disease, Huntington's disease, anti-amyotrophic lateral sclerosis, Chagas disease and other less distributed diseases is discussed. This review covers the in vitro, ex vivo and in vivo studies concerning the prevention and treatment of neurological disorders (on the biochemical and gene expression levels) by phenolic acids.

Keywords: benzoic acids; central nervous system; cinnamic acids; glial cell; neuroinflammation; neurological disorder; neuron; neuroprotection; polyphenols.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

**Figure 1**
Chemical structures of phenolic acids discussed in this work.

See this image and copyright information in PMC

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References

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[1] Mattila P., Hellström J., Törrönen R. Phenolic acids in berries, fruits, and beverages. J. Agric. Food Chem. 2006;54:7193–7199. doi: 10.1021/jf0615247. - DOI - PubMed

[2] Mattila P., Hellström J., Törrönen R. Phenolic acids in berries, fruits, and beverages. J. Agric. Food Chem. 2006;54:7193–7199. doi: 10.1021/jf0615247. - DOI - PubMed

[3] Grosso G., Estruch R. Nut consumption and age-related disease. Maturitas. 2016;84:11–16. doi: 10.1016/j.maturitas.2015.10.014. - DOI - PubMed

[4] Grosso G., Estruch R. Nut consumption and age-related disease. Maturitas. 2016;84:11–16. doi: 10.1016/j.maturitas.2015.10.014. - DOI - PubMed

[5] Crozier A., Jaganath I.B., Clifford M.N. Dietary phenolics: Chemistry, bioavailability and effects on health. Nat. Prod. Rep. 2009;26:1001–1043. doi: 10.1039/b802662a. - DOI - PubMed

[6] Crozier A., Jaganath I.B., Clifford M.N. Dietary phenolics: Chemistry, bioavailability and effects on health. Nat. Prod. Rep. 2009;26:1001–1043. doi: 10.1039/b802662a. - DOI - PubMed

[7] Van Hung P. Phenolic compounds of cereals and their antioxidant capacity. Crit. Rev. Food Sci. Nutr. 2016;56:25–35. doi: 10.1080/10408398.2012.708909. - DOI - PubMed

[8] Van Hung P. Phenolic compounds of cereals and their antioxidant capacity. Crit. Rev. Food Sci. Nutr. 2016;56:25–35. doi: 10.1080/10408398.2012.708909. - DOI - PubMed

[9] Liu X., Yan Y., Li F., Zhang D. Fruit and vegetable consumption and the risk of depression: A meta-analysis. Nutrition. 2016;32:296–302. doi: 10.1016/j.nut.2015.09.009. - DOI - PubMed

[10] Liu X., Yan Y., Li F., Zhang D. Fruit and vegetable consumption and the risk of depression: A meta-analysis. Nutrition. 2016;32:296–302. doi: 10.1016/j.nut.2015.09.009. - DOI - PubMed

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The Neuroprotective Effects of Phenolic Acids: Molecular Mechanism of Action

Affiliations

The Neuroprotective Effects of Phenolic Acids: Molecular Mechanism of Action

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Affiliations

Abstract

Conflict of interest statement

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