Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Dec;62(12):4828-31.
doi: 10.1128/JVI.62.12.4828-4831.1988.

Influence of env and long terminal repeat sequences on the tissue tropism of avian leukosis viruses

D W Brown  1 , H L Robinson
Affiliations

Influence of env and long terminal repeat sequences on the tissue tropism of avian leukosis viruses

D W Brown et al. J Virol. 1988 Dec.

Abstract

Adsorption and penetration of retroviruses into eucaryotic cells is mediated by retroviral envelope glycoproteins interacting with host receptors. Recombinant avian leukosis viruses (ALVs) differing only in envelope determinants that interact with host receptors for subgroup A or E ALVs have been found to have unexpectedly distinctive patterns of tissue-specific replication. Recombinants of both subgroups were highly expressed in bursal lymphocytes as well as in cultured chicken embryo fibroblasts. In contrast, the subgroup A but not subgroup E host range allowed high levels of expression in skeletal muscle, while subgroup E but not subgroup A envelope glycoproteins permitted efficient replication in the thymus. A subgroup B virus (RAV-2), like the subgroup E viruses, demonstrated a distinct bursal and thymic tropism, further supporting the theory that genes encoding receptors for subgroup B and E viruses are allelic. The source of long terminal repeats (LTRs) or adjacent sequences also influenced tissue-specific replication, with the LTRs from endogenous virus RAV-0 supporting efficient replication in the bursa and thymus but not in skeletal muscle. These results indicate that ALV env and LTR regions are responsible for unexpectedly distinctive tissue tropisms.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Virology. 1966 Nov;30(3):368-74 - PubMed
    1. Exp Cell Res. 1961 Sep;24:508-20 - PubMed
    1. Virology. 1975 Oct;67(2):327-34 - PubMed
    1. Virology. 1975 Oct;67(2):553-65 - PubMed
    1. Virology. 1976 Jan;69(1):50-62 - PubMed

Publication types

LinkOut - more resources