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. 2017 Oct;89(10):1734-1742.
doi: 10.1002/jmv.24838. Epub 2017 May 23.

Genetic variability of human respiratory syncytial virus group B in Panama reveals a novel genotype BA14

Leyda E Ábrego  1 , Adriana Delfraro  2 , Danilo Franco  1   3 , Juan Castillo  4 , Marlene Castillo  1 , Brechla Moreno  1 , Sandra López-Vergès  1 , Juan M Pascale  3   4 , Juan Arbiza  2
Affiliations

Genetic variability of human respiratory syncytial virus group B in Panama reveals a novel genotype BA14

Leyda E Ábrego et al. J Med Virol. 2017 Oct.

Abstract

In Panama, human respiratory syncytial virus (HRSV) is responsible of 20-40% of acute respiratory infections in children under 5 years old. Currently, little is known about the genetic variability of HRSV in Central America and the Caribbean. Recently, we reported the genetic variability of HRSV-A, however; no studies on HRSV-B in Panama have been described yet. In this study, 24 sequences of Panamanian HRSV-B, from children (<5 years) with acute respiratory infections (ARI), collected from July 2008 to November 2012 were analyzed. All sequences share the characteristic 60-nt duplication of the BA strains. Six Panamanian strains grouped with the BA10 genotype and 12 samples clustered together in a separate monophyletic clade with an aLRT support value of 0.92 and an intra-group p-distance less than 0.07. This fulfills the criteria to consider a new genotype in HRSV, which we named BA14 genotype. Another six strains remain unclassified, but closely related to BA9, BA11, or the new BA14 genotypes, according to their genetic p-distance. Different amino acid substitutions in the Panamanian HRSV-B strains were observed, some previously described and others found only on Panamanian strains. This study contributes to the knowledge of the genetic variability and evolution of HRSV in Central America.

Keywords: acute respiratory infections (ARI); genotype; group B; human respiratory syncytial virus.

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