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Review
. 2017 Apr;43(2):63-69.
doi: 10.5125/jkaoms.2017.43.2.63. Epub 2017 Apr 25.

The role of nuclear factor I-C in tooth and bone development

Song Yi Roh  1 , Joo-Cheol Park  1
Affiliations
Review

The role of nuclear factor I-C in tooth and bone development

Song Yi Roh et al. J Korean Assoc Oral Maxillofac Surg. 2017 Apr.

Abstract

Nuclear factor I-C (NFI-C) plays a pivotal role in various cellular processes such as odontoblast and osteoblast differentiation. Nfic-deficient mice showed abnormal tooth and bone formation. The transplantation of Nfic-expressing mouse bone marrow stromal cells rescued the impaired bone formation in Nfic-/- mice. Studies suggest that NFI-C regulate osteogenesis and dentinogenesis in concert with several factors including transforming growth factor-β1, Krüppel-like factor 4, and β-catenin. This review will focus on the function of NFI-C during tooth and bone formation and on the relevant pathways that involve NFI-C.

Keywords: Dentinogenesis; Nuclear factor I-C; Osteogenesis; Osteoporosis.

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Conflict of interest statement

Conflict of Interest: No potential conflict of interest relevant to this article was reported.

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