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. 1988 Dec 1;62(11):2363-9.
doi: 10.1002/1097-0142(19881201)62:11<2363::aid-cncr2820621118>3.0.co;2-c.

The association of hepatocellular carcinoma in childhood with hepatitis B virus infection

I Leuschner  1 , D Harms, D Schmidt
Affiliations

The association of hepatocellular carcinoma in childhood with hepatitis B virus infection

I Leuschner et al. Cancer. .

Abstract

Eleven cases of hepatocellular carcinoma (HCC) in childhood were investigated by immunohistochemistry for association with hepatitis B virus (HBV) infection. Seven of 11 cases (64%) demonstrated positivity for hepatitis B surface antigen (HBsAG), whereas all 11 were negative for hepatitis B core antigen (HBcAG). Cirrhosis was absent in all cases, and other causes for HCC in childhood were not found. All children with HBV-associated HCC died within 6 months of diagnosis. The median survival time of these children was 2 months. Only one child with HCC of trabecular subtype without HBV association is still living after 18 months. However, this child has metastases and a local recurrence. Three other children with HCC of fibrolamellar subtype are free of disease after 2, 5, and 6 years, respectively. The high number of cases of HBV-associated HCC shows the important role of HBV infection as an etiologic factor for the development of childhood HCC in middle Europe.

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