Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 May;55(5):319-329.
doi: 10.1007/s12275-017-7075-2. Epub 2017 Apr 29.

Primary lymphocyte infection models for KSHV and its putative tumorigenesis mechanisms in B cell lymphomas

Sangmin Kang  1 , Jinjong Myoung  2
Affiliations
Review

Primary lymphocyte infection models for KSHV and its putative tumorigenesis mechanisms in B cell lymphomas

Sangmin Kang et al. J Microbiol. 2017 May.

Abstract

Kaposi's sarcoma-associated herpesvirus (KSHV) is the latest addition to the human herpesvirus family. Unlike alpha- and beta-herpesvirus subfamily members, gamma-herpesviruses, including Epstein-Barr virus (EBV) and KSHV, cause various tumors in humans. KSHV primarily infects endothelial and B cells in vivo, and is associated with at least three malignancies: Kaposi's sarcoma and two B cell lymphomas, respectively. Although KSHV readily infects endothelial cells in vitro and thus its pathogenic mechanisms have been extensively studied, B cells had been refractory to KSHV infection. As such, functions of KSHV genes have mostly been elucidated in endothelial cells in the context of viral infection but not in B cells. Whether KSHV oncogenes, defined in endothelial cells, play the same roles in the tumorigenesis of B cells remains an open question. Only recently, through a few ground-breaking studies, B cell infection models have been established. In this review, those models will be compared and contrasted and putative mechanisms of KSHV-induced B cell transformation will be discussed.

Keywords: B cell; KSHV; infection model; lymphoma.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Cancer Res. 2008 Jun 15;68(12 ):4640-8 - PubMed
    1. J Clin Invest. 2011 Mar;121(3):1130-40 - PubMed
    1. Blood. 2006 Jul 1;108(1):141-51 - PubMed
    1. Cell Host Microbe. 2012 Feb 16;11(2):167-80 - PubMed
    1. AIDS. 2000 May 5;14(7):899-902 - PubMed

LinkOut - more resources