Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2017 Apr 11;8(15):24593-24603.
doi: 10.18632/oncotarget.15598.

Characteristics and comparison of colorectal cancer incidence in Beijing with other regions in the world

Zhongmin Li  1 , Lei Yang  2 , Changzheng Du  3 , Xuedong Fang  1 , Ning Wang  2 , Jin Gu  3   4   5
Affiliations
Multicenter Study

Characteristics and comparison of colorectal cancer incidence in Beijing with other regions in the world

Zhongmin Li et al. Oncotarget. .

Abstract

Background: Population-based epidemiologic studies about colorectal cancer are lacking in China. This study aims to provide a basis for colorectal cancer screening and prevention, through analysis and comparisons the characteristics of the trends in colorectal cancer incidence in Beijing and selected representative regions.

Results: The annual incidence rate in Beijing region increased significantly, from 9.40/100,000 in 1998 to 18.61/100,000 in 2012. The stratified rate showed that the incidence of distal colon adenocarcinoma increased substantially in men, especially in those aged > 75 years and residing in urban areas. Although the incidence rate in Beijing is still lower than in Shanghai, Jiashan, and Hong Kong in China, it is increasing rapidly. Further, the incidence rate in Beijing is lower than in New York, Oxford and Osaka, but higher than in Mumbai and Kyadondo. The incidence trend in Beijing is increasing especially in older groups, while in other regions such as New York, it is decreasing in these age groups.

Materials and methods: Colorectal cancer incidence data were obtained from Beijing Cancer Registry and Cancer Incidence in Five Continents Plus database. All incidence rates were age-standardized according to Segi's world population. Incidence trends were characterized by calculating the annual percent changes using the Joinpoint Regression Program.

Conclusions: Compared with other regions, Beijing has a medium level of colorectal cancer incidence, however, it is increasing significantly. There are obvious differences in the cancer subsite, sex and age distributions between Beijing and other regions. Prevention and screening of colorectal cancer in Beijing should be strengthened.

Keywords: Beijing; colorectal cancer; incidence; population-based; trend.

PubMed Disclaimer

Conflict of interest statement

CONFLICTS OF INTEREST

We declare that we have no conflicts of interest.

Figures

Figure 1
Figure 1. Trends of colorectal cancer incidence rate in Beijing between 1998 and 2012
Figure 2
Figure 2
Trends of colorectal cancer incidence in Beijing by (A) male to female rate ratio; (B) colon to rectal rate ratio; (C) proximal and distal colon; (D) age; (E) pathological type; (F) areas (urban/rural).
Figure 3
Figure 3
Trends of (A) colorectal cancer incidence rate; (B) male to female rate ratio; (C) colon to rectal rate ratio in Chinese four representative regions between 1998 and 2007.
Figure 4
Figure 4
Trends of (A) colorectal cancer incidence rate; (B) male to female rate ratio; (C) colon to rectal rate ratio in international representative regions between 1998 and 2007.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Chen WQ, Zheng RS, Zeng HM, Zhang SW, Zhao P, He J. Trend analysis and projection of cancer incidence in China between 1989 and 2008. Chinese journal of oncology. 2012;34:517–24. - PubMed
    1. Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ, He J. Cancer statistics in China, 2015. CA Cancer J Clin. 2016;66:115–132. - PubMed
    1. Liu S, Zheng R, Zhang M, Zhang S, Sun X, Chen W. Incidence and mortality of colorectal cancer in China, 2011. Chinese journal of cancer research. 2015;27:22–8. - PMC - PubMed
    1. Axtell LM, Chiazze L., Jr Changing relative frequency of cancers of the colon and rectum in the United States. Cancer. 1966;19:750–4. - PubMed
    1. Schub R, Steinheber FU. Rightward shift of colon cancer. A feature of the aging gut. Journal of clinical gastroenterology. 1986;8:630–4. - PubMed

Publication types