Mark it for destruction: a novel role of mRNA methylation in maternal-to-zygotic transition†

doi:10.1093/biolre/iox016

Comment

. 2017 Apr 1;96(4):829-830.

doi: 10.1093/biolre/iox016.

Mark it for destruction: a novel role of mRNA methylation in maternal-to-zygotic transition†

Wei Yan^{1

2}

Affiliations

¹ Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, Nevada, USA.
² Department of Biology, University of Nevada, Reno, Nevada, USA.

PMID: 28371885
PMCID: PMC6279102
DOI: 10.1093/biolre/iox016

Comment

Mark it for destruction: a novel role of mRNA methylation in maternal-to-zygotic transition†

Wei Yan. Biol Reprod. 2017.

. 2017 Apr 1;96(4):829-830.

doi: 10.1093/biolre/iox016.

Author

Wei Yan^{1

2}

Affiliations

¹ Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, Nevada, USA.
² Department of Biology, University of Nevada, Reno, Nevada, USA.

PMID: 28371885
PMCID: PMC6279102
DOI: 10.1093/biolre/iox016

No abstract available

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Figures

**Figure 1.**
Schematic illustration of the role of m6A in the regulation of maternal transcript turnover during MZT in zebrafish. Wild-type (WT) eggs contain a large number of m6A-marked maternal transcripts, which will degrade in a YTHDF2-dependent manner during MZT. The *ythdf2* knockout (KO) eggs lack YTHDF2 and thus, m6A-marked maternal transcripts fail to be removed and the persistent maternal transcripts disrupt normal MZT, leading to a complete block in late G2 and early M phase of the cell cycle in one-cell embryos.

See this image and copyright information in PMC

Comment on

m⁶A-dependent maternal mRNA clearance facilitates zebrafish maternal-to-zygotic transition.
Zhao BS, Wang X, Beadell AV, Lu Z, Shi H, Kuuspalu A, Ho RK, He C. Zhao BS, et al. Nature. 2017 Feb 23;542(7642):475-478. doi: 10.1038/nature21355. Epub 2017 Feb 13. Nature. 2017. PMID: 28192787 Free PMC article.

References

1. Desrosiers R, Friderici K, Rottman F. Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells. Proc Natl Acad Sci USA 1974; 71:3971–3975. - PMC - PubMed
1. Jia G, Fu Y, Zhao X, Dai Q, Zheng G, Yang Y, Yi C, Lindahl T, Pan T, Yang YG, He C. N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat Chem Biol 2011; 7:885–887. - PMC - PubMed
1. Meyer KD, Saletore Y, Zumbo P, Elemento O, Mason CE, Jaffrey SR. Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell 2012; 149:1635–1646. - PMC - PubMed
1. Dominissini D, Moshitch-Moshkovitz S, Schwartz S, Salmon-Divon M, Ungar L, Osenberg S, Cesarkas K, Jacob-Hirsch J, Amariglio N, Kupiec M, Sorek R, Rechavi G. Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature 2012; 485:201–206. - PubMed
1. Yue Y, Liu J, He C. RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation. Genes Dev 2015; 29:1343–1355. - PMC - PubMed

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[1] Desrosiers R, Friderici K, Rottman F. Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells. Proc Natl Acad Sci USA 1974; 71:3971–3975. - PMC - PubMed

[2] Desrosiers R, Friderici K, Rottman F. Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells. Proc Natl Acad Sci USA 1974; 71:3971–3975. - PMC - PubMed

[3] Jia G, Fu Y, Zhao X, Dai Q, Zheng G, Yang Y, Yi C, Lindahl T, Pan T, Yang YG, He C. N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat Chem Biol 2011; 7:885–887. - PMC - PubMed

[4] Jia G, Fu Y, Zhao X, Dai Q, Zheng G, Yang Y, Yi C, Lindahl T, Pan T, Yang YG, He C. N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat Chem Biol 2011; 7:885–887. - PMC - PubMed

[5] Meyer KD, Saletore Y, Zumbo P, Elemento O, Mason CE, Jaffrey SR. Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell 2012; 149:1635–1646. - PMC - PubMed

[6] Meyer KD, Saletore Y, Zumbo P, Elemento O, Mason CE, Jaffrey SR. Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell 2012; 149:1635–1646. - PMC - PubMed

[7] Dominissini D, Moshitch-Moshkovitz S, Schwartz S, Salmon-Divon M, Ungar L, Osenberg S, Cesarkas K, Jacob-Hirsch J, Amariglio N, Kupiec M, Sorek R, Rechavi G. Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature 2012; 485:201–206. - PubMed

[8] Dominissini D, Moshitch-Moshkovitz S, Schwartz S, Salmon-Divon M, Ungar L, Osenberg S, Cesarkas K, Jacob-Hirsch J, Amariglio N, Kupiec M, Sorek R, Rechavi G. Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature 2012; 485:201–206. - PubMed

[9] Yue Y, Liu J, He C. RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation. Genes Dev 2015; 29:1343–1355. - PMC - PubMed

[10] Yue Y, Liu J, He C. RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation. Genes Dev 2015; 29:1343–1355. - PMC - PubMed

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Mark it for destruction: a novel role of mRNA methylation in maternal-to-zygotic transition†

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Mark it for destruction: a novel role of mRNA methylation in maternal-to-zygotic transition†

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