Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer
Affiliations
- 1 Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA.
- 2 Department of Gynecologic Oncology, Moffitt Cancer Center, Tampa, Florida, USA.
- 3 Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, UK.
- 4 Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
- 5 Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
- 6 Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
- 7 Division of Biomedical Statistics and Informatics, Department of Health Science Research, Mayo Clinic, Rochester, Minnesota, USA.
- 8 Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina, USA.
- 9 Department of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota, USA.
- 10 Center for Bioinformatics and Functional Genomics, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
- 11 Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
- 12 Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
- 13 Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec City, Quebec, Canada.
- 14 Department of Clinical Genetics, Academic Medical Center, Amsterdam, the Netherlands.
- 15 Radboud University Medical Center, Radboud Institute for Health Sciences, Department for Health Evidence, Nijmegen, the Netherlands.
- 16 Netherlands Comprehensive Cancer Organisation, Utrecht, the Netherlands.
- 17 Center for Inherited Disease Research, Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
- 18 Yorkshire Regional Genetics Service, Chapel Allerton Hospital, Leeds, UK.
- 19 Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
- 20 Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
- 21 Genetic Epidemiology Research Institute, UCI Center for Cancer Genetics Research and Prevention, School of Medicine, University of California-Irvine, Irvine, California, USA.
- 22 Department of Epidemiology, University of California-Irvine, Irvine, California, USA.
- 23 N.N. Alexandrov National Cancer Centre of Belarus, Minsk, Belarus.
- 24 'Agii Anargiri' Cancer Hospital, Athens, Greece.
- 25 Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian Albrechts University Kiel, Kiel, Germany.
- 26 Department of Breast Medical Oncology and Clinical Cancer Genetics Program, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
- 27 Department of Oncology and Pathology, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.
- 28 Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Milan, Italy.
- 29 Department of Medical Oncology, University Hospital, Vall d'Hebron, Barcelona, Spain.
- 30 Gynaecology Unit, Royal Marsden Hospital, London, UK.
- 31 Bâtiment Cheney D, Centre Léon Bérard, Lyon, France.
- 32 Laboratory of Cell Biology, Department of Pathology, Landspitali, Reykjavik, Iceland.
- 33 BMC (Biomedical Centre), Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
- 34 Department of Gynecologic Oncology, Oregon Health &Science University, Portland, Oregon, USA.
- 35 Knight Cancer Institute, Oregon Health &Science University, Portland, Oregon, USA.
- 36 Department of Gynecology and Obstetrics, Universtiy Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg, Erlangen, Germany.
- 37 Division of Epidemiology, Department of Medicine, Vanderbilt School of Medicine, Nashville, Tennessee, USA.
- 38 Vanderbilt Epidemiology Center, Department of Medicine, Vanderbilt Medical School, Nashville, Tennessee, USA.
- 39 Institute for Medicine and Public Health, Vanderbilt School of Medicine, Nashville, Tennessee, USA.
- 40 Vanderbilt-Ingram Cancer Center, Vanderbilt School of Medicine, Nashville, Tennessee, USA.
- 41 Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid, Spain.
- 42 Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain.
- 43 Institute of Biochemistry and Genetics, Ufa Science Center, Russian Academy of Sciences, Ufa, Russian Federation.
- 44 Division of Gynecologic Oncology, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada.
- 45 Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
- 46 Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.
- 47 Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway.
- 48 Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
- 49 Clinical Cancer Genetics for the City of Hope, Clinical Cancer Genetics Community Research Network, Duarte, California, USA.
- 50 Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, the Netherlands.
- 51 Radiation Oncology Research Unit, Hannover Medical School, Hannover, Germany.
- 52 Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark.
- 53 Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy.
- 54 Department of Oncology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden.
- 55 Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
- 56 Cancer Research UK (CRUK) Cambridge Institute, University of Cambridge, Cambridge, UK.
- 57 Department of Clinical Genetics, Royal Devon and Exeter Hospital, Exeter, UK.
- 58 Department of Cancer Epidemiology, University Hospital, Lund, Lund University, Lund, Sweden.
- 59 Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada.
- 60 Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia.
- 61 Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d'Investigació Biomèdica de Girona), Catalan Institute of Oncology, Girona, Spain.
- 62 Service de Génétique Oncologique, Institut Curie, Paris, France.
- 63 Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
- 64 Department of Medicine, Huntsman Cancer Institute, Salt Lake City, Utah, USA.
- 65 Molecular Oncology Laboratory, Hospital Clínico San Carlos, IdISSC (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Madrid, Spain.
- 66 Section of Genetic Oncology, Department of Laboratory Medicine, University and University Hospital of Pisa, Pisa, Italy.
- 67 Cancer Genetics Laboratory, Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
- 68 Department of Pathology, University of Melbourne, Parkville, Victoria, Australia.
- 69 Cancer Pathology and Prevention, Division of Cancer Prevention and Population Sciences, Roswell Park Cancer Institute, Buffalo, New York, USA.
- 70 Department of Obstetrics and Gynecology, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA.
- 71 Cancer Risk Program, University of California, San Francisco, San Francisco, California, USA.
- 72 Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
- 73 University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
- 74 Centre for Cancer Research, Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales, Australia.
- 75 Department of Gynaecological Oncology, Westmead Hospital, Sydney, New South Wales, Australia.
- 76 Unité de Recherche en Santé des Populations, Centre des Maladies du Sein Deschênes-Fabia, Centre de Recherche FRSQ du Centre Hospitalier Affilié Universitaire de Québec, Quebec City, Quebec, Canada.
- 77 Departments of Pediatrics and Medicine, Columbia University, New York, New York, USA.
- 78 Center for Medical Genetics, Ghent University, Ghent, Belgium.
- 79 Division of Epidemiology, Biostatistics and Preventative Medicine, Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico, USA.
- 80 Sheffield Clinical Genetics Service, Sheffield Children's Hospital, Sheffield, UK.
- 81 Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
- 82 Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
- 83 Social &Scientific Systems, Inc., Durham, North Carolina, USA.
- 84 Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.
- 85 Department of Genetics and Fundamental Medicine, Bashkir State University, Ufa, Russian Federation.
- 86 Department of Pathology and Laboratory Diagnostics, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
- 87 Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
- 88 Department of Clinical Genetics, South Glasgow University Hospitals, Glasgow, UK.
- 89 Unité d'Oncogénétique, ICO-Centre René Gauducheau, Nantes, France.
- 90 Oncogenetics Group, Vall d'Hebron Institute of Oncology, Barcelona, Spain.
- 91 Clinical and Molecular Genetics Area, Vall d'Hebron University Hospital. Barcelona, Spain.
- 92 Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California, USA.
- 93 Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
- 94 Cancer Genetics Laboratory, Department of Genetics, University of Pretoria, Pretoria, South Africa.
- 95 Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.
- 96 Nutrition and Metabolism Section, International Agency for Research on Cancer (IARC-WHO), Lyon, France.
- 97 Institute of Biology and Molecular Genetics, Universidad de Valladolid (IBGM-UVA), Valladolid, Spain.
- 98 Department of Gynecology, Jena University Hospital-Friedrich Schiller University, Jena, Germany.
- 99 Institute of Human Genetics, Münster, Germany.
- 100 University of Southampton Faculty of Medicine, Southampton University Hospitals NHS Trust, Southampton, UK.
- 101 Oncogenetics Team, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, UK.
- 102 Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
- 103 Institute of Human Genetics, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany.
- 104 Department of Biostatistics and Bioinformatics, Roswell Park Institute, Buffalo, New York, USA.
- 105 Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
- 106 Genomic Medicine, Manchester Academic Health Sciences Centre, University of Manchester, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK.
- 107 Division of Hematology and Oncology, Department of Medicine, UCLA David Geffen School of Medicine, Los Angeles, California, USA.
- 108 Laboratoire de Génétique Chromosomique, Hôtel Dieu Centre Hospitalier, Chambéry, France.
- 109 Department of Surgery and Cancer, Imperial College London, London, UK.
- 110 Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Aghia Paraskevi Attikis, Athens, Greece.
- 111 Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montreal, Quebec, Canada.
- 112 Department of Medical Oncology, Papageorgiou, Hospital, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece.
- 113 Biostatistics and Informatics Shared Resource, University of Kansas Medical Center, Kansas City, Kansas, USA.
- 114 Harvard T.H. Chan School of Public Health and Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
- 115 Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Ramat Gan, Israel.
- 116 Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel.
- 117 Division of Cancer Prevention and Control Research, Jonsson Comprehensive Cancer Center, UCLA Schools of Medicine and Public Health, Los Angeles, California, USA.
- 118 Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
- 119 Centre of Familial Breast and Ovarian Cancer, Department of Medical Genetics, Institute of Human Genetics, University Würzburg, Würzburg, Germany.
- 120 Women's Cancer, Institute for Women's Health, University College London, London, UK.
- 121 Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
- 122 Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
- 123 Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
- 124 Beatson West of Scotland Cancer Centre, Glasgow, UK.
- 125 Ontario Cancer Genetics Network: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
- 126 Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA.
- 127 Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah, USA.
- 128 Department of Medicine, Royal Marsden Hospital, London, UK.
- 129 Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA.
- 130 Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
- 131 Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.
- 132 Center for Familial Breast and Ovarian Cancer, Center for Integrated Oncology (CIO) and Center for Molecular Medicine Cologne (CMMC), University Hospital Cologne, Cologne, Germany.
- 133 Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
- 134 Division of Nutritional Epidemiology, Department of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
- 135 Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
- 136 Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
- 137 Institute of Genetic Medicine, Centre for Life, Newcastle-upon-Tyne Hospitals NHS Trust, Newcastle-upon-Tyne, UK.
- 138 Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
- 139 Clinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany.
- 140 Medical Genetics Unit, St George's University of London, London, UK.
- 141 Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
- 142 Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.
- 143 Molecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark.
- 144 Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, the Netherlands.
- 145 Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, the Netherlands.
- 146 Center for Immunotherapy, Roswell Park Cancer Institute, Buffalo, New York, USA.
- 147 Center for Medical Genetics, NorthShore University HealthSystem, University of Chicago Pritzker School of Medicine, Evanston, Illinois, USA.
- 148 Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
- 149 Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
- 150 British Columbia Cancer Agency, Vancouver, British Columbia, Canada.
- 151 N.N. Petrov Institute of Oncology, St. Petersburg, Russian Federation.
- 152 Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
- 153 Department of Statistical Science, Duke University, Durham, North Carolina, USA.
- 154 Clinical Genetics, Guy's and St Thomas' NHS Foundation Trust, London, UK.
- 155 Familial Cancer Centre, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
- 156 Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.
- 157 Department of Molecular and Regenerative Medicine, Hematology, Oncology and Transfusion Medicine Center, Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania.
- 158 State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania.
- 159 Department of Obstetrics and Gynecology, Lund University Hospital, Lund, Sweden.
- 160 Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark.
- 161 Department of Epidemiology, Cancer Prevention Institute of California, Fremont, California, USA.
- 162 Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK.
- 163 Department of Gynaecology and Obstetrics, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany.
- 164 Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
- 165 Department of Surgery, Breast Care Center, Daerim St. Mary's Hospital, Seoul, Republic of Korea.
- 166 Department of Pathology, University of Calgary, Calgary, Alberta, Canada.
- 167 Department of Clinical Genetics, Odense University Hospital, Odense, Denmark.
- 168 Hong Kong Hereditary Breast Cancer Family Registry, Hong Kong.
- 169 Department of Surgery, University of Hong Kong, Hong Kong.
- 170 Cancer Genetics Center and Department of Surgery, Hong Kong Sanatorium and Hospital, Hong Kong.
- 171 Vesalius Research Center, VIB, Leuven, Belgium.
- 172 Laboratory for Translational Genetics, Department of Oncology, KU Leuven, Leuven, Belgium.
- 173 Public Health Division of Gipuzkoa, Regional Government of the Basque Country, Donostia-San Sebastian, Spain.
- 174 CIBER of Epidemiology and Public Health, Madrid, Spain.
- 175 Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain.
- 176 Cancer Control Research, BC Cancer Agency, Vancouver, British Columbia, Canada.
- 177 Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA.
- 178 Department of Surgery, Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea.
- 179 Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, New York, USA.
- 180 Département de Génétique, Centre Hospitalier Universitaire de Grenoble, Grenoble, France.
- 181 Institut Curie, PSL Research Unviersity and INSERM U900, Paris, France.
- 182 Mines Paris Tech, Fontainebleau, France.
- 183 College of Pharmacy and Health Sciences, Texas Southern University, Houston, Texas, USA.
- 184 Cancer Center Wolfsburg, Clinics of Gynaecology, Wolfsburg, Germany.
- 185 Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota, USA.
- 186 Department of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
- 187 Department of Gynecologic Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
- 188 Juliane Marie Centre, Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
- 189 INSERM U1052, CNRS UMR 5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Centre Léon Bérard, Lyon, France.
- 190 Ovarian Cancer Research (OVCARE) Program-Gynecologic Tissue Bank, Vancouver General Hospital and BC Cancer Agency, Vancouver, British Columbia, Canada.
- 191 Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, California, USA.
- 192 Public Health Ontario, Toronto, Ontario, Canada.
- 193 Institute of Cancer Sciences, University of Glasgow, Wolfson Wohl Cancer Research Centre, Beatson Institute for Cancer Research, Glasgow, UK.
- 194 Department of Clinical Genetics, VU University Medical Centre, Amsterdam, the Netherlands.
- 195 Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.
- 196 Department of Human Genetics, Radboud University Medical Centre, Nijmegen, the Netherlands.
- 197 Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
- 198 Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
- 199 Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, USA.
- 200 Ovarian Cancer Center of Excellence, Womens Cancer Research Program, Magee-Womens Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA.
- 201 Department of Obstetrics and Gynecology, Oregon Health &Science University, Portland, Oregon, USA.
- 202 Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy.
- 203 Department of Laboratory Medicine and Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Ontario, Canada.
- 204 Clinical Genetics Research Laboratory, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
- 205 Department of Pathology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
- 206 University of Texas School of Public Health, Houston, Texas, USA.
- 207 Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
- 208 Invitae Corporation, San Francisco, California, USA.
- 209 Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
- 210 Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary.
- 211 Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center, Chicago, Illinois, USA.
- 212 Department of Oncology, Lund University Hospital, Lund, Sweden.
- 213 Department of Obstetrics and Gynecology, Ohio State University and the James Cancer Center, Columbus, Ohio, USA.
- 214 West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Edgbaston, Birmingham, UK.
- 215 Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.
- 216 Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research, London, UK.
- 217 Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute-ISPO, Florence, Italy.
- 218 Unit of Medical Genetics, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy.
- 219 Cancer Research UK Clinical Trials Unit, Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.
- 220 Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
- 221 Section of Molecular Diagnostics, Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark.
- 222 Department of Genetics, Portuguese Oncology Institute, Porto, Portugal.
- 223 IFOM, FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, Italy.
- 224 Department of Obstetrics and Gynecology, Medical University of Vienna and Comprehensive Cancer Center, Vienna, Austria.
- 225 Division of Cancer Medicine, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.
- 226 NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Buffalo, New York, USA.
- 227 Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
- 228 Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
- 229 South East of Scotland Regional Genetics Service, Western General Hospital, Edinburgh, UK.
- 230 Service de Génétique Clinique Chromosomique et Moléculaire, Centre Hospitalier Universitaire de St Etienne, St Etienne, France.
- 231 Translational Research Laboratory, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, Barcelona, Spain.
- 232 Unité d'Oncogénétique, Centre Hospitalier Universitaire Arnaud de Villeneuve, Montpellier, France.
- 233 Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Milan, Italy.
- 234 Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden.
- 235 Clalit National Israeli Cancer Control Center, Haifa, Israel.
- 236 Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Haifa, Israel.
- 237 Department of Pathology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
- 238 Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
- 239 Division of Gynecologic Oncology, NorthShore University HealthSystem, University of Chicago, Evanston, Illinois, USA.
- 240 Hereditary Endocrine Cancer Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain.
- 241 Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands.
- 242 Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
- 243 Epidemiology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, USA.
- 244 Clinical Cancer Genetics Program, Division of Human Genetics, Department of Internal Medicine, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, USA.
- 245 Facultés de Médecin, Université Paris-Sud, Villejuif, France.
- 246 Institut Gustave Roussy, Villejuif, France.
- 247 Human Genetics Foundation (HuGeF), Turin, Italy.
- 248 Facultés de Médecin, Université Paris-Saclay, Paris, France.
- 249 Department of Hematology and Oncology, University of Kansas Medical Center, Kansas City, Kansas, USA.
- 250 Department of Gynaecological Oncology, Glasgow Royal Infirmary, Glasgow, UK.
- 251 North East Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Trust, London, UK.
- 252 Département Oncologie Génétique, Institut Paoli-Calmettes, Marseille, France.
- 253 Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, Victoria, Australia.
- 254 Institute of Human Genetics, Hannover Medical School, Hannover, Germany.
- 255 Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, USA.
- 256 Epidemiology Center, College of Medicine, University of South Florida, Tampa, Florida, USA.
- 257 Institute of Human Genetics, Department of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany.
- 258 Division of Breast Cancer Research, Institute of Cancer Research, London, UK.
- 259 National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA.
- 260 Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal.
- 261 Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia.
- 262 University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia.
- 263 Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
- 264 Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
- 265 Magee-Womens Hospital of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
- 266 Latvian Biomedical Research and Study Centre, Riga, Latvia.
- 267 Ovarian Cancer Research (OVCARE) Program-Cheryl Brown Ovarian Cancer Outcomes Unit (CBOCOU), BC Cancer Agency, Vancouver, British Columbia, Canada.
- 268 Department of Medical Genetics, Addenbrooke's Treatment Centre, Addenbrooke's Hospital, Cambridge, UK.
- 269 Division of Human Cancer Genetics, Departments of Internal Medicine and Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, USA.
- 270 Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
- 271 Hellenic Health Foundation, Athens, Greece.
- 272 WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece.
- 273 Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
- 274 Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology, Radboud University Medical Centre, Nijmegen, the Netherlands.
- 275 Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
- 276 Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands.
- 277 Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.
- 278 Institute of Medical and Human Genetics, Charité Universitätsmedizin, Campus Virchov Klinikum, Berlin, Germany.
- 279 Fundación Pública Galega de Medicina Xenómica, Servizo Galego de Saúde (SERGAS), Instituto de Investigación Sanitaria (IDIS), Santiago de Compostela, Spain.
- 280 Grupo de Medicina Xenómica, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Universidade de Santiago de Compostela (USC), Santiago de Compostela, Spain.
- 281 Vanderbilt Genetics Institute and Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
- 282 Oxford Regional Genetics Service, Churchill Hospital, Oxford, UK.
- 283 Institute of Human Genetics, University Hospital, Leipzig, Germany.
- 284 Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany.
- 285 Population Health Department, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
- 286 Biostatistics and Computational Biology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, USA.
- 287 Clinical Cancer Genetics, City of Hope, Duarte, California, USA.
- 288 Department of Data Management Science, Stanford University School of Medicine, Stanford, California, USA.
- 289 Departments of Human Genetics and Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands.
- 290 Women's College Research Institute, University of Toronto, Toronto, Ontario, Canada.
- 291 Center for Genomic Medicine, Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.
- 292 Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA.
- 293 School of Women's and Children's Health, Lowy Cancer Research Centre, University of New South Wales, Sydney, New South Wales, Australia.
- 294 Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.
- 295 Department of Molecular Medicine, University La Sapienza, Rome, Italy.
- 296 Community and Population Health Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.
- 297 Department of Preventive Medicine, College of Medicine, Seoul National University, Seoul, Republic of Korea.
- 298 Seoul National University Cancer Research Institute, Seoul, Republic of Korea.
- 299 Department of Biomedical Science, Graduate School, Seoul National University, Seoul, Republic of Korea.
- 300 Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
- 301 Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut, USA.
- 302 Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.
- PMID: 28346442
- PMCID: PMC5612337
- DOI: 10.1038/ng.3826
Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer
Authors
Affiliations
- 1 Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA.
- 2 Department of Gynecologic Oncology, Moffitt Cancer Center, Tampa, Florida, USA.
- 3 Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, UK.
- 4 Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
- 5 Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
- 6 Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
- 7 Division of Biomedical Statistics and Informatics, Department of Health Science Research, Mayo Clinic, Rochester, Minnesota, USA.
- 8 Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina, USA.
- 9 Department of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota, USA.
- 10 Center for Bioinformatics and Functional Genomics, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
- 11 Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
- 12 Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
- 13 Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec City, Quebec, Canada.
- 14 Department of Clinical Genetics, Academic Medical Center, Amsterdam, the Netherlands.
- 15 Radboud University Medical Center, Radboud Institute for Health Sciences, Department for Health Evidence, Nijmegen, the Netherlands.
- 16 Netherlands Comprehensive Cancer Organisation, Utrecht, the Netherlands.
- 17 Center for Inherited Disease Research, Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
- 18 Yorkshire Regional Genetics Service, Chapel Allerton Hospital, Leeds, UK.
- 19 Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
- 20 Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
- 21 Genetic Epidemiology Research Institute, UCI Center for Cancer Genetics Research and Prevention, School of Medicine, University of California-Irvine, Irvine, California, USA.
- 22 Department of Epidemiology, University of California-Irvine, Irvine, California, USA.
- 23 N.N. Alexandrov National Cancer Centre of Belarus, Minsk, Belarus.
- 24 'Agii Anargiri' Cancer Hospital, Athens, Greece.
- 25 Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian Albrechts University Kiel, Kiel, Germany.
- 26 Department of Breast Medical Oncology and Clinical Cancer Genetics Program, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
- 27 Department of Oncology and Pathology, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.
- 28 Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Milan, Italy.
- 29 Department of Medical Oncology, University Hospital, Vall d'Hebron, Barcelona, Spain.
- 30 Gynaecology Unit, Royal Marsden Hospital, London, UK.
- 31 Bâtiment Cheney D, Centre Léon Bérard, Lyon, France.
- 32 Laboratory of Cell Biology, Department of Pathology, Landspitali, Reykjavik, Iceland.
- 33 BMC (Biomedical Centre), Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
- 34 Department of Gynecologic Oncology, Oregon Health &Science University, Portland, Oregon, USA.
- 35 Knight Cancer Institute, Oregon Health &Science University, Portland, Oregon, USA.
- 36 Department of Gynecology and Obstetrics, Universtiy Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg, Erlangen, Germany.
- 37 Division of Epidemiology, Department of Medicine, Vanderbilt School of Medicine, Nashville, Tennessee, USA.
- 38 Vanderbilt Epidemiology Center, Department of Medicine, Vanderbilt Medical School, Nashville, Tennessee, USA.
- 39 Institute for Medicine and Public Health, Vanderbilt School of Medicine, Nashville, Tennessee, USA.
- 40 Vanderbilt-Ingram Cancer Center, Vanderbilt School of Medicine, Nashville, Tennessee, USA.
- 41 Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid, Spain.
- 42 Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain.
- 43 Institute of Biochemistry and Genetics, Ufa Science Center, Russian Academy of Sciences, Ufa, Russian Federation.
- 44 Division of Gynecologic Oncology, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada.
- 45 Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
- 46 Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.
- 47 Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway.
- 48 Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
- 49 Clinical Cancer Genetics for the City of Hope, Clinical Cancer Genetics Community Research Network, Duarte, California, USA.
- 50 Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, the Netherlands.
- 51 Radiation Oncology Research Unit, Hannover Medical School, Hannover, Germany.
- 52 Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark.
- 53 Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy.
- 54 Department of Oncology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden.
- 55 Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
- 56 Cancer Research UK (CRUK) Cambridge Institute, University of Cambridge, Cambridge, UK.
- 57 Department of Clinical Genetics, Royal Devon and Exeter Hospital, Exeter, UK.
- 58 Department of Cancer Epidemiology, University Hospital, Lund, Lund University, Lund, Sweden.
- 59 Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada.
- 60 Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia.
- 61 Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d'Investigació Biomèdica de Girona), Catalan Institute of Oncology, Girona, Spain.
- 62 Service de Génétique Oncologique, Institut Curie, Paris, France.
- 63 Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
- 64 Department of Medicine, Huntsman Cancer Institute, Salt Lake City, Utah, USA.
- 65 Molecular Oncology Laboratory, Hospital Clínico San Carlos, IdISSC (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Madrid, Spain.
- 66 Section of Genetic Oncology, Department of Laboratory Medicine, University and University Hospital of Pisa, Pisa, Italy.
- 67 Cancer Genetics Laboratory, Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
- 68 Department of Pathology, University of Melbourne, Parkville, Victoria, Australia.
- 69 Cancer Pathology and Prevention, Division of Cancer Prevention and Population Sciences, Roswell Park Cancer Institute, Buffalo, New York, USA.
- 70 Department of Obstetrics and Gynecology, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA.
- 71 Cancer Risk Program, University of California, San Francisco, San Francisco, California, USA.
- 72 Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
- 73 University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
- 74 Centre for Cancer Research, Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales, Australia.
- 75 Department of Gynaecological Oncology, Westmead Hospital, Sydney, New South Wales, Australia.
- 76 Unité de Recherche en Santé des Populations, Centre des Maladies du Sein Deschênes-Fabia, Centre de Recherche FRSQ du Centre Hospitalier Affilié Universitaire de Québec, Quebec City, Quebec, Canada.
- 77 Departments of Pediatrics and Medicine, Columbia University, New York, New York, USA.
- 78 Center for Medical Genetics, Ghent University, Ghent, Belgium.
- 79 Division of Epidemiology, Biostatistics and Preventative Medicine, Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico, USA.
- 80 Sheffield Clinical Genetics Service, Sheffield Children's Hospital, Sheffield, UK.
- 81 Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
- 82 Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
- 83 Social &Scientific Systems, Inc., Durham, North Carolina, USA.
- 84 Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.
- 85 Department of Genetics and Fundamental Medicine, Bashkir State University, Ufa, Russian Federation.
- 86 Department of Pathology and Laboratory Diagnostics, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
- 87 Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
- 88 Department of Clinical Genetics, South Glasgow University Hospitals, Glasgow, UK.
- 89 Unité d'Oncogénétique, ICO-Centre René Gauducheau, Nantes, France.
- 90 Oncogenetics Group, Vall d'Hebron Institute of Oncology, Barcelona, Spain.
- 91 Clinical and Molecular Genetics Area, Vall d'Hebron University Hospital. Barcelona, Spain.
- 92 Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California, USA.
- 93 Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
- 94 Cancer Genetics Laboratory, Department of Genetics, University of Pretoria, Pretoria, South Africa.
- 95 Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.
- 96 Nutrition and Metabolism Section, International Agency for Research on Cancer (IARC-WHO), Lyon, France.
- 97 Institute of Biology and Molecular Genetics, Universidad de Valladolid (IBGM-UVA), Valladolid, Spain.
- 98 Department of Gynecology, Jena University Hospital-Friedrich Schiller University, Jena, Germany.
- 99 Institute of Human Genetics, Münster, Germany.
- 100 University of Southampton Faculty of Medicine, Southampton University Hospitals NHS Trust, Southampton, UK.
- 101 Oncogenetics Team, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, UK.
- 102 Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
- 103 Institute of Human Genetics, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany.
- 104 Department of Biostatistics and Bioinformatics, Roswell Park Institute, Buffalo, New York, USA.
- 105 Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
- 106 Genomic Medicine, Manchester Academic Health Sciences Centre, University of Manchester, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK.
- 107 Division of Hematology and Oncology, Department of Medicine, UCLA David Geffen School of Medicine, Los Angeles, California, USA.
- 108 Laboratoire de Génétique Chromosomique, Hôtel Dieu Centre Hospitalier, Chambéry, France.
- 109 Department of Surgery and Cancer, Imperial College London, London, UK.
- 110 Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Aghia Paraskevi Attikis, Athens, Greece.
- 111 Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montreal, Quebec, Canada.
- 112 Department of Medical Oncology, Papageorgiou, Hospital, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece.
- 113 Biostatistics and Informatics Shared Resource, University of Kansas Medical Center, Kansas City, Kansas, USA.
- 114 Harvard T.H. Chan School of Public Health and Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
- 115 Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Ramat Gan, Israel.
- 116 Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel.
- 117 Division of Cancer Prevention and Control Research, Jonsson Comprehensive Cancer Center, UCLA Schools of Medicine and Public Health, Los Angeles, California, USA.
- 118 Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
- 119 Centre of Familial Breast and Ovarian Cancer, Department of Medical Genetics, Institute of Human Genetics, University Würzburg, Würzburg, Germany.
- 120 Women's Cancer, Institute for Women's Health, University College London, London, UK.
- 121 Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
- 122 Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
- 123 Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
- 124 Beatson West of Scotland Cancer Centre, Glasgow, UK.
- 125 Ontario Cancer Genetics Network: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
- 126 Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA.
- 127 Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah, USA.
- 128 Department of Medicine, Royal Marsden Hospital, London, UK.
- 129 Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA.
- 130 Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
- 131 Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.
- 132 Center for Familial Breast and Ovarian Cancer, Center for Integrated Oncology (CIO) and Center for Molecular Medicine Cologne (CMMC), University Hospital Cologne, Cologne, Germany.
- 133 Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
- 134 Division of Nutritional Epidemiology, Department of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
- 135 Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
- 136 Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
- 137 Institute of Genetic Medicine, Centre for Life, Newcastle-upon-Tyne Hospitals NHS Trust, Newcastle-upon-Tyne, UK.
- 138 Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
- 139 Clinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany.
- 140 Medical Genetics Unit, St George's University of London, London, UK.
- 141 Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
- 142 Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.
- 143 Molecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark.
- 144 Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, the Netherlands.
- 145 Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, the Netherlands.
- 146 Center for Immunotherapy, Roswell Park Cancer Institute, Buffalo, New York, USA.
- 147 Center for Medical Genetics, NorthShore University HealthSystem, University of Chicago Pritzker School of Medicine, Evanston, Illinois, USA.
- 148 Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
- 149 Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
- 150 British Columbia Cancer Agency, Vancouver, British Columbia, Canada.
- 151 N.N. Petrov Institute of Oncology, St. Petersburg, Russian Federation.
- 152 Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
- 153 Department of Statistical Science, Duke University, Durham, North Carolina, USA.
- 154 Clinical Genetics, Guy's and St Thomas' NHS Foundation Trust, London, UK.
- 155 Familial Cancer Centre, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
- 156 Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.
- 157 Department of Molecular and Regenerative Medicine, Hematology, Oncology and Transfusion Medicine Center, Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania.
- 158 State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania.
- 159 Department of Obstetrics and Gynecology, Lund University Hospital, Lund, Sweden.
- 160 Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark.
- 161 Department of Epidemiology, Cancer Prevention Institute of California, Fremont, California, USA.
- 162 Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK.
- 163 Department of Gynaecology and Obstetrics, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany.
- 164 Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
- 165 Department of Surgery, Breast Care Center, Daerim St. Mary's Hospital, Seoul, Republic of Korea.
- 166 Department of Pathology, University of Calgary, Calgary, Alberta, Canada.
- 167 Department of Clinical Genetics, Odense University Hospital, Odense, Denmark.
- 168 Hong Kong Hereditary Breast Cancer Family Registry, Hong Kong.
- 169 Department of Surgery, University of Hong Kong, Hong Kong.
- 170 Cancer Genetics Center and Department of Surgery, Hong Kong Sanatorium and Hospital, Hong Kong.
- 171 Vesalius Research Center, VIB, Leuven, Belgium.
- 172 Laboratory for Translational Genetics, Department of Oncology, KU Leuven, Leuven, Belgium.
- 173 Public Health Division of Gipuzkoa, Regional Government of the Basque Country, Donostia-San Sebastian, Spain.
- 174 CIBER of Epidemiology and Public Health, Madrid, Spain.
- 175 Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain.
- 176 Cancer Control Research, BC Cancer Agency, Vancouver, British Columbia, Canada.
- 177 Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA.
- 178 Department of Surgery, Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea.
- 179 Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, New York, USA.
- 180 Département de Génétique, Centre Hospitalier Universitaire de Grenoble, Grenoble, France.
- 181 Institut Curie, PSL Research Unviersity and INSERM U900, Paris, France.
- 182 Mines Paris Tech, Fontainebleau, France.
- 183 College of Pharmacy and Health Sciences, Texas Southern University, Houston, Texas, USA.
- 184 Cancer Center Wolfsburg, Clinics of Gynaecology, Wolfsburg, Germany.
- 185 Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota, USA.
- 186 Department of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
- 187 Department of Gynecologic Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
- 188 Juliane Marie Centre, Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
- 189 INSERM U1052, CNRS UMR 5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Centre Léon Bérard, Lyon, France.
- 190 Ovarian Cancer Research (OVCARE) Program-Gynecologic Tissue Bank, Vancouver General Hospital and BC Cancer Agency, Vancouver, British Columbia, Canada.
- 191 Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, California, USA.
- 192 Public Health Ontario, Toronto, Ontario, Canada.
- 193 Institute of Cancer Sciences, University of Glasgow, Wolfson Wohl Cancer Research Centre, Beatson Institute for Cancer Research, Glasgow, UK.
- 194 Department of Clinical Genetics, VU University Medical Centre, Amsterdam, the Netherlands.
- 195 Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.
- 196 Department of Human Genetics, Radboud University Medical Centre, Nijmegen, the Netherlands.
- 197 Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
- 198 Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
- 199 Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, USA.
- 200 Ovarian Cancer Center of Excellence, Womens Cancer Research Program, Magee-Womens Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA.
- 201 Department of Obstetrics and Gynecology, Oregon Health &Science University, Portland, Oregon, USA.
- 202 Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy.
- 203 Department of Laboratory Medicine and Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Ontario, Canada.
- 204 Clinical Genetics Research Laboratory, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
- 205 Department of Pathology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
- 206 University of Texas School of Public Health, Houston, Texas, USA.
- 207 Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
- 208 Invitae Corporation, San Francisco, California, USA.
- 209 Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
- 210 Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary.
- 211 Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center, Chicago, Illinois, USA.
- 212 Department of Oncology, Lund University Hospital, Lund, Sweden.
- 213 Department of Obstetrics and Gynecology, Ohio State University and the James Cancer Center, Columbus, Ohio, USA.
- 214 West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Edgbaston, Birmingham, UK.
- 215 Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.
- 216 Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research, London, UK.
- 217 Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute-ISPO, Florence, Italy.
- 218 Unit of Medical Genetics, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy.
- 219 Cancer Research UK Clinical Trials Unit, Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.
- 220 Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
- 221 Section of Molecular Diagnostics, Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark.
- 222 Department of Genetics, Portuguese Oncology Institute, Porto, Portugal.
- 223 IFOM, FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, Italy.
- 224 Department of Obstetrics and Gynecology, Medical University of Vienna and Comprehensive Cancer Center, Vienna, Austria.
- 225 Division of Cancer Medicine, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.
- 226 NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Buffalo, New York, USA.
- 227 Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
- 228 Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
- 229 South East of Scotland Regional Genetics Service, Western General Hospital, Edinburgh, UK.
- 230 Service de Génétique Clinique Chromosomique et Moléculaire, Centre Hospitalier Universitaire de St Etienne, St Etienne, France.
- 231 Translational Research Laboratory, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, Barcelona, Spain.
- 232 Unité d'Oncogénétique, Centre Hospitalier Universitaire Arnaud de Villeneuve, Montpellier, France.
- 233 Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Milan, Italy.
- 234 Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden.
- 235 Clalit National Israeli Cancer Control Center, Haifa, Israel.
- 236 Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Haifa, Israel.
- 237 Department of Pathology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
- 238 Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
- 239 Division of Gynecologic Oncology, NorthShore University HealthSystem, University of Chicago, Evanston, Illinois, USA.
- 240 Hereditary Endocrine Cancer Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain.
- 241 Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands.
- 242 Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
- 243 Epidemiology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, USA.
- 244 Clinical Cancer Genetics Program, Division of Human Genetics, Department of Internal Medicine, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, USA.
- 245 Facultés de Médecin, Université Paris-Sud, Villejuif, France.
- 246 Institut Gustave Roussy, Villejuif, France.
- 247 Human Genetics Foundation (HuGeF), Turin, Italy.
- 248 Facultés de Médecin, Université Paris-Saclay, Paris, France.
- 249 Department of Hematology and Oncology, University of Kansas Medical Center, Kansas City, Kansas, USA.
- 250 Department of Gynaecological Oncology, Glasgow Royal Infirmary, Glasgow, UK.
- 251 North East Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Trust, London, UK.
- 252 Département Oncologie Génétique, Institut Paoli-Calmettes, Marseille, France.
- 253 Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, Victoria, Australia.
- 254 Institute of Human Genetics, Hannover Medical School, Hannover, Germany.
- 255 Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, USA.
- 256 Epidemiology Center, College of Medicine, University of South Florida, Tampa, Florida, USA.
- 257 Institute of Human Genetics, Department of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany.
- 258 Division of Breast Cancer Research, Institute of Cancer Research, London, UK.
- 259 National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA.
- 260 Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal.
- 261 Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia.
- 262 University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia.
- 263 Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
- 264 Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
- 265 Magee-Womens Hospital of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
- 266 Latvian Biomedical Research and Study Centre, Riga, Latvia.
- 267 Ovarian Cancer Research (OVCARE) Program-Cheryl Brown Ovarian Cancer Outcomes Unit (CBOCOU), BC Cancer Agency, Vancouver, British Columbia, Canada.
- 268 Department of Medical Genetics, Addenbrooke's Treatment Centre, Addenbrooke's Hospital, Cambridge, UK.
- 269 Division of Human Cancer Genetics, Departments of Internal Medicine and Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, USA.
- 270 Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
- 271 Hellenic Health Foundation, Athens, Greece.
- 272 WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece.
- 273 Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
- 274 Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology, Radboud University Medical Centre, Nijmegen, the Netherlands.
- 275 Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
- 276 Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands.
- 277 Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.
- 278 Institute of Medical and Human Genetics, Charité Universitätsmedizin, Campus Virchov Klinikum, Berlin, Germany.
- 279 Fundación Pública Galega de Medicina Xenómica, Servizo Galego de Saúde (SERGAS), Instituto de Investigación Sanitaria (IDIS), Santiago de Compostela, Spain.
- 280 Grupo de Medicina Xenómica, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Universidade de Santiago de Compostela (USC), Santiago de Compostela, Spain.
- 281 Vanderbilt Genetics Institute and Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
- 282 Oxford Regional Genetics Service, Churchill Hospital, Oxford, UK.
- 283 Institute of Human Genetics, University Hospital, Leipzig, Germany.
- 284 Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany.
- 285 Population Health Department, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
- 286 Biostatistics and Computational Biology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, USA.
- 287 Clinical Cancer Genetics, City of Hope, Duarte, California, USA.
- 288 Department of Data Management Science, Stanford University School of Medicine, Stanford, California, USA.
- 289 Departments of Human Genetics and Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands.
- 290 Women's College Research Institute, University of Toronto, Toronto, Ontario, Canada.
- 291 Center for Genomic Medicine, Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.
- 292 Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA.
- 293 School of Women's and Children's Health, Lowy Cancer Research Centre, University of New South Wales, Sydney, New South Wales, Australia.
- 294 Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.
- 295 Department of Molecular Medicine, University La Sapienza, Rome, Italy.
- 296 Community and Population Health Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.
- 297 Department of Preventive Medicine, College of Medicine, Seoul National University, Seoul, Republic of Korea.
- 298 Seoul National University Cancer Research Institute, Seoul, Republic of Korea.
- 299 Department of Biomedical Science, Graduate School, Seoul National University, Seoul, Republic of Korea.
- 300 Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
- 301 Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut, USA.
- 302 Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.
- PMID: 28346442
- PMCID: PMC5612337
- DOI: 10.1038/ng.3826
Abstract
To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and 9q31.1) and one for endometrioid EOC (5q12.3). We then performed meta-analysis on the results for high-grade serous ovarian cancer with the results from analysis of 31,448 BRCA1 and BRCA2 mutation carriers, including 3,887 mutation carriers with EOC. This identified three additional susceptibility loci at 2q13, 8q24.1 and 12q24.31. Integrated analyses of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, including OBFC1, a new candidate susceptibility gene for low-grade and borderline serous EOC.
Conflict of interest statement
The authors declare no competing financial interests related to this manuscript.
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