Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Jun:196:61-70.
doi: 10.1016/j.cbpc.2017.03.014. Epub 2017 Mar 23.

Signaling pathways involved in metal-based nanomaterial toxicity towards aquatic organisms

Amélie Châtel  1 , Catherine Mouneyrac  2
Affiliations
Review

Signaling pathways involved in metal-based nanomaterial toxicity towards aquatic organisms

Amélie Châtel et al. Comp Biochem Physiol C Toxicol Pharmacol. 2017 Jun.

Abstract

Environmental risk assessment of engineered nanomaterials (ENMs) is an emergent field since nanotechnology industry is rapidly growing due to the interesting physicochemical properties of nanomaterials. Metal-based nanomaterials are among the most rapidly commercialized materials and their toxicity towards aquatic animals has been investigated at different levels of the biological organization. The objective of this synthesis review is to give an overview of the signaling molecules that have a key role in metal-based NM mediated cytotoxicity in both marine and freshwater organisms. Since toxicity of metal-based NMs could be (partly) due to metal dissolution, this review only highlights studies that showed a specific nano-effect. From this bibliographic study, three mechanisms (detoxification, immunomodulation and genotoxicity) have been selected as they represent the major cell defense mechanisms and the most studied ones following ENM exposure. This better understanding of NM-mediated cytotoxicity may provide a sound basis for designing environmentally safer nanomaterials.

Keywords: Apoptosis; Cell signaling; Genotoxicity; Immune system; Nanoparticle; Oxidative stress.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

MeSH terms

LinkOut - more resources