Breast cancer cells: Focus on the consequences of epithelial-to-mesenchymal transition
- PMID: 28336365
- DOI: 10.1016/j.biocel.2017.03.014
Breast cancer cells: Focus on the consequences of epithelial-to-mesenchymal transition
Abstract
Breast cancers are highly heterogeneous and successful treatment of those subtypes with a high frequency of metastases and resistance to clinically available therapies remains a challenge. An understanding of mechanisms which may contribute to this heterogeneity and generation of more resilient cancer cells is therefore essential. Epithelial-to-mesenchymal transition (EMT) is a dynamic two-way process that occurs during embryonic development and wound healing whereby epithelial cells can gain plasticity and switch to a mesenchymal-like phenotype. EMT has received interest from cancer researchers due to its potential role in processes important in cancer progression and metastasis. Recent evidence has revealed a clear association between EMT and resistance to therapeutics. Targeting of EMT and/or the mesenchymal-like phenotype may be a promising avenue for future therapeutic intervention. This review provides a brief summary of the functional consequences of EMT in breast cancer, with a focus on the mesenchymal-like phenotype.
Keywords: Breast carcinoma; Heterogeneity; Mesenchymal; Plasticity.
Copyright © 2017 Elsevier Ltd. All rights reserved.
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