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Review
. 2017 Jun;29(3):131-143.
doi: 10.1080/1120009X.2017.1306183. Epub 2017 Mar 24.

Liposomal amphotericin B (AmBisome®) at beginning of its third decade of clinical use

Franco Aversa  1 , Alessandro Busca  2 , Anna Candoni  3 , Simone Cesaro  4 , Corrado Girmenia  5 , Mario Luppi  6 , Anna Maria Nosari  7 , Livio Pagano  8 , Luigina Romani  9 , Giuseppe Rossi  10 , Adriano Venditti  11 , Andrea Novelli  12
Affiliations
Review

Liposomal amphotericin B (AmBisome®) at beginning of its third decade of clinical use

Franco Aversa et al. J Chemother. 2017 Jun.

Abstract

Haematologists have been using liposomal amphotericin-B (L-AMB) since 1993 and despite the introduction of several novel antifungal agents over the past decade, their propensity to prescribe L-AMB remains unchanged. Although antifungal guidelines strongly recommend voriconazole as the drug of choice in the treatment of probable and proven invasive fungal disease (IFD), L-AMB is widely used in the real life because of its several advantages in terms of wide anti-mould spectrum, tolerability and efficacy. Furthermore, the concept that L-AMB is endowed with immune-modulating effects, which may have a role in fighting IFD, represent another reason for its use in patients who do not tolerate an excess of inflammation. Finally, given its tolerability and safety, L-AMB is an ideal partner for combining therapy, particularly with echinocandins with which shares the immunological properties that result in a synergistic effect.

Keywords: Antifungal activity; Antifungal prophylaxis; Immune-pharmacology; Invasive fungal infection; Liposomal amphotericin.

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