Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Mar 1;58(3):1764-1765.
doi: 10.1167/iovs.17-21697.

Chronic, Systemic Interleukin-18 Does Not Promote Macular Degeneration or Choroidal Neovascularization

Affiliations

Chronic, Systemic Interleukin-18 Does Not Promote Macular Degeneration or Choroidal Neovascularization

Scott W Canna et al. Invest Ophthalmol Vis Sci. .
No abstract available

PubMed Disclaimer

Figures

Figure
Figure
Timeline of serum IL-18 measurements and fundoscopic examinations. The x-axis represents time since initial National Institutes of Health evaluation, often years after symptom onset. Serial measurement of serum IL-18 (closed circles) was compared with instances of ophthalmologist's fundoscopic examination (X). Patients are represented by different colors. All fundoscopic examinations were documented to be normal, save one patient with self-resolving steroid-induced papilledema (pink, see text). ULN, upper limit of normal.

Similar articles

Cited by

References

    1. Tarallo V,, Hirano Y,, Gelfand BD,, et al. DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88. Cell. 2012; 149: 847–859. - PMC - PubMed
    1. Doyle SL,, Campbell M,, Ozaki E,, et al. NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components. Nat Med. 2012; 18: 791–798. - PMC - PubMed
    1. Doyle SL,, Ozaki E,, Brennan K,, et al. IL-18 attenuates experimental choroidal neovascularization as a potential therapy for wet age-related macular degeneration. Sci Transl Med. 2014; 6: 230ra. - PubMed
    1. Hirano Y,, Yasuma T,, Mizutani T,, et al. IL-18 is not therapeutic for neovascular age-related macular degeneration. Nat Med. 2014; 20: 1372–1375. - PMC - PubMed
    1. Doyle SL,, Adamson P,, Lopez FJ,, Humphries P,, Campbell M. Reply to IL-18 is not therapeutic for neovascular age-related macular degeneration. Nat Med. 2014; 20: 1376–1377. - PubMed

MeSH terms