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. 2017;56(3):145-149.
doi: 10.3960/jslrt.56.145.

TET2 mutation in diffuse large B-cell lymphoma

Yoko Kubuki  1 , Takumi Yamaji, Tomonori Hidaka, Takuro Kameda, Kotaro Shide, Masaaki Sekine, Ayako Kamiunten, Keiichi Akizuki, Haruko Shimoda, Yuuki Tahira, Kenichi Nakamura, Hiroo Abe, Tadashi Miike, Hisayoshi Iwakiri, Yoshihiro Tahara, Mitsue Sueta, Shojiro Yamamoto, Satoru Hasuike, Kenji Nagata, Akira Kitanaka, Kazuya Shimoda
Affiliations

TET2 mutation in diffuse large B-cell lymphoma

Yoko Kubuki et al. J Clin Exp Hematop. 2017.

Abstract

Ten-eleven translocation-2 (TET2) mutation is frequently observed in myeloid malignancies, and loss-of-function of TET2 is essential for the initiation of malignant hematopoiesis. TET2 mutation presents across disease entities and was reported in lymphoid malignancies. We investigated TET2 mutations in 27 diffuse large B-cell lymphoma (DLBCL) patients and found a frameshift mutation in 1 case (3.7%). TET2 mutation occurred in some populations of DLBCL patients and was likely involved in the pathogenesis of their malignancies.

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Conflict of interest statement

CONFLICT OF INTEREST: The authors declare no conflict of interest

Figures

Figure 1
Figure 1
TET2 mutation in DLBCL and TET2 protein A. Sanger sequence of TET2 in case 16. Electropherogram of TET2 exon3 sequences showing the monoallelic mutation c.2057_2058delGAinsAGG (note in red). The DNA and corresponding amino acid sequences of the wild-type and mutant TET2 alleles are also shown. B. A schematic representation of the TET2 protein. The arrowhead shows the position corresponding to the mutation. This mutation led to premature termination p.R686KfsX7. Truncated-form mutant TET2 lacks the cysteine-rich domain (CD) and double stranded b-helix (DSBH) 2OG-Fe(II)-dependent dioxygenase domain.
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References

    1. Alizadeh AA, Eisen MB, Davis RE, Ma C, Lossos IS, et al. : Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 403: 503-511, 2000. 10.1038/35000501 - DOI - PubMed
    1. Pasqualucci L, Dominguez-Sola D, Chiarenza A, Fabbri G, Grunn A, et al. : Inactivating mutations of acetyltransferase genes in B-cell lymphoma. Nature 471: 189-195, 2011. 10.1038/nature09730 - DOI - PMC - PubMed
    1. Ngo VN, Young RM, Schmitz R, Jhavar S, Xiao W, et al. : Oncogenically active MYD88 mutations in human lymphoma. Nature 470: 115-119, 2011. 10.1038/nature09671 - DOI - PMC - PubMed
    1. Young RM, Staudt LM: Targeting pathological B cell receptor signalling in lymphoid malignancies. Nat Rev Drug Discov 12: 229-243, 2013. 10.1038/nrd3937 - DOI - PMC - PubMed
    1. Ko M, Bandukwala HS, An J, Lamperti ED, Thompson EC, et al. : Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice. Proc Natl Acad Sci USA 108: 14566-14571, 2011. 10.1073/pnas.1112317108 - DOI - PMC - PubMed