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Review
. 2017 Apr 15;130(8):1347-1353.
doi: 10.1242/jcs.199471. Epub 2017 Mar 21.

The tubulin code at a glance

Sudarshan Gadadhar  1   2 , Satish Bodakuntla  1   2 , Kathiresan Natarajan  1   2 , Carsten Janke  3   2
Affiliations
Review

The tubulin code at a glance

Sudarshan Gadadhar et al. J Cell Sci. .

Abstract

Microtubules are key cytoskeletal elements of all eukaryotic cells and are assembled of evolutionarily conserved α-tubulin-β-tubulin heterodimers. Despite their uniform structure, microtubules fulfill a large diversity of functions. A regulatory mechanism to control the specialization of the microtubule cytoskeleton is the 'tubulin code', which is generated by (i) expression of different α- and β-tubulin isotypes, and by (ii) post-translational modifications of tubulin. In this Cell Science at a Glance article and the accompanying poster, we provide a comprehensive overview of the molecular components of the tubulin code, and discuss the mechanisms by which these components contribute to the generation of functionally specialized microtubules.

Keywords: Detyrosination; Glutamylation; Glycylation; Tubulin code; Tubulin isotypes.

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