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. 2017 Mar 15;195(6):829-831.
doi: 10.1164/rccm.201608-1558LE.

The Nasal Methylome: A Key to Understanding Allergic Asthma

Ivana V Yang  1   2 , Adam Richards  1 , Elizabeth J Davidson  1 , Allen D Stevens  2 , Christena A Kolakowski  2 , Richard J Martin  1   2 , David A Schwartz  1   2
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The Nasal Methylome: A Key to Understanding Allergic Asthma

Ivana V Yang et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Differentially methylated single-CpG probes or differentially methylated positions in bronchial and nasal epithelia, but not peripheral blood mononuclear cells (PBMCs), are associated with asthma after controlling for age, sex, technical variables, and batch effects in white adult nonsmoker subjects. Manhattan plot of the false discovery rate–adjusted P values (q values) for disease status (asthma/control) from the tissue-specific linear model. PBMC, top panel; nasal epithelia, middle panel; and bronchial epithelia, bottom panel. Probes with q < 0.05 in the tissue-specific linear model are highlighted by darker larger symbols.
Figure 2.
Figure 2.
DNA methylation changes are associated with changes in gene expression in nasal and bronchial epithelia. Expression changes of genes nearest differentially methylated positions from Figure 1. x-Axis: methylation difference is represented by the mean percentage methylation difference in subjects with asthma compared with control subjects; y-axis: expression difference is represented by the mean fold change in subjects with asthma compared with control subjects (on the log2 scale). Nasal epithelia, left panel; bronchial epithelia, right panel. The blue symbols represent hypomethylated genes that were associated with increased gene expression as well as some hypermethylated genes associated with decreased gene expression. The red symbols represent methylation changes that were not associated with expected gene expression differences.
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