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. 2017 Nov;22(6):257-264.
doi: 10.1080/13510002.2016.1215643. Epub 2016 Sep 22.

Hyperglycaemia, oxidative stress and inflammatory markers

Eugene G Butkowski  1 , Herbert F Jelinek  1   2   3
Affiliations

Hyperglycaemia, oxidative stress and inflammatory markers

Eugene G Butkowski et al. Redox Rep. 2017 Nov.

Abstract

Introduction: The increasing prevalence of hyperglycaemia implicates a state of oxidative stress and inflammation. Traditional and emerging biomarkers associated with increasing hyperglycaemia were assessed to clarify their role they play in hyperglycaemia.

Results: 309 participants attending a rural diabetic screening program were categorised into control and quintile groups based upon glucose levels: 1st quintile - <4.5 mmol/L and 4th, 5th quintile - >6.1 mmol/L. Significant results were obtained for anthropometric data and biochemical markers - glucose, HbA1c and total cholesterol (P < 0.001); oxidative stress: glutathione (P < 0.001), glutathione:glutathione disulfide and 8-hydroxy-2-deoxyguanosine (P < 0.05). Interleukin -1β and inflammatory marker ratios IL-6/IL-10, IL-1β/IL-10, MCP-1/IL-10, IGF-1/IL-10 and IL-6/IL-1β were significant (P < 0.05).

Conclusion: This study provided further evidence that inflammatory and oxidative stress biomarkers may contribute to diagnostic information associated with preclinical increases in BGL. Further we have provided a unique study in the analysis of ratios of inflammatory biomarkers and correlations with increasing BGL.

Keywords: 8-hydroxy-2′-deoxyguanosine; Type 2 diabetes mellitus; body mass index; cardiovascular disease; glutathione; glutathione disulphide; impaired fasting glucose; insulin like growth factor 1; interleukin 10; interleukin 1β; interleukin-6; monocyte chemoattractant protein 1; oxidative stress; prediabetes; risk factors.

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Conflict of interest statement

Conflict of interest The authors declare that there is no conflict of interest regarding the publication of this article.

Figures

Figure 1.
Figure 1.
Medication usage chart comparison. Dmeds, diabetic medication; Anti-HT, anti-hypertensives; NSAID, non steroidal anti-inflammatory drugs.
Figure 2.
Figure 2.
CVD, HT, and T2DM status. T2DM, Type 2 diabetes mellitus; CVD, cardiovascular disease; HT, hypertension.
See this image and copyright information in PMC

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