Dynamic changes of epigenetic signatures during chondrogenic and adipogenic differentiation of mesenchymal stem cells

doi:10.1016/j.biopha.2017.02.093

Review

. 2017 May:89:719-731.

doi: 10.1016/j.biopha.2017.02.093. Epub 2017 Mar 6.

Dynamic changes of epigenetic signatures during chondrogenic and adipogenic differentiation of mesenchymal stem cells

Navid Saidi¹, Majdedin Ghalavand², Mohammad Sadegh Hashemzadeh², Ruhollah Dorostkar³, Hamed Mohammadi⁴, Ahmad Mahdian-Shakib⁵

Affiliations

¹ Department of Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran.
² Applied Virology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
³ Applied Virology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Electronic address: R.dorost@yahoo.com.
⁴ Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
⁵ Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

PMID: 28273634
DOI: 10.1016/j.biopha.2017.02.093

Review

Dynamic changes of epigenetic signatures during chondrogenic and adipogenic differentiation of mesenchymal stem cells

Navid Saidi et al. Biomed Pharmacother. 2017 May.

. 2017 May:89:719-731.

doi: 10.1016/j.biopha.2017.02.093. Epub 2017 Mar 6.

Authors

Navid Saidi¹, Majdedin Ghalavand², Mohammad Sadegh Hashemzadeh², Ruhollah Dorostkar³, Hamed Mohammadi⁴, Ahmad Mahdian-Shakib⁵

Affiliations

¹ Department of Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran.
² Applied Virology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
³ Applied Virology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Electronic address: R.dorost@yahoo.com.
⁴ Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
⁵ Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

PMID: 28273634
DOI: 10.1016/j.biopha.2017.02.093

Abstract

Extensive studies have been performed to clarify the processes during which mesenchymal stem cells (MSCs) differentiate into their lineage fates. In vitro differentiation of MSCs into distinct lineages have attracted the focus of a large number of clinical investigations. Although the gene expression profiling during differentiation of MSC toward bone, cartilage, and adipocytes is well established, the master regulators by which MSC fate can be controlled are not entirely determined. During differentiation of MSCs into a special cell fate, epigenetic mechanisms considered as the primary mediators that suppress the irrelevant genes and activate the genes required for a specific cell lineage. This review dedicated to addressing the changes of various epigenetic mechanisms, including DNA methylation, histone modifications, and micro-RNAs during chondrogenic and adipogenic differentiation of MSC.

Keywords: Chondrogenic and adipogenic differentiation; Epigenetics; MSCs.

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Dynamic changes of epigenetic signatures during chondrogenic and adipogenic differentiation of mesenchymal stem cells

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Dynamic changes of epigenetic signatures during chondrogenic and adipogenic differentiation of mesenchymal stem cells

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