Peripheral Corticotropin Releasing Factor Signaling Inhibits Gastric Emptying: Mechanisms of Action and Role in Stress-related Gastric Alterations of Motor Function
- PMID: 28245760
- DOI: 10.2174/1381612823666170228142428
Peripheral Corticotropin Releasing Factor Signaling Inhibits Gastric Emptying: Mechanisms of Action and Role in Stress-related Gastric Alterations of Motor Function
Abstract
The activation of Corticotrophin Releasing-Factor (CRF) receptors in the brain is well established to coordinate the endocrine, behavioral, autonomic and visceral responses to stress. In addition, CRF receptors are also expressed within the gut where they exert biological actions and play a role in modulating stress-related gastrointestinal function. In particular, peripheral injection of CRF and related peptides, urocortin 1, 2 or 3 inhibit Gastric Emptying (GE) and alters fasted and fed pattern of gastroduodenal motility in several experimental species. Urocortin 1 interacts synergistically with cholecystokin-8 to inhibit gastric emptying in lean mice which is no longer observed in diet-induced obese rats. In in vitro circular or longitudinal muscle preparation of rat antrum, CRF and urocortin 1 and 2 suppressed spontaneous contractile activity. CRF and urocortins interact with the CRF receptor 2 (CRF-R2) to inhibit gastric motor function monitored both in vivo and in vitro. The CRF-R2 mediated inhibition of antral and corpus contractility involves a direct action on gastric myenteric neurons where CRF-R2 is expressed and may also involve the activation of serotonin acting on 5-HT3 receptor. The involvement of peripheral CRF receptors in gastric motor alterations occurring under stress conditions are stressors specific with CRF-R2 mediating the early phase of gastric ileus induced by abdominal surgery and the delayed emptying elicited by acute restraint stress. However gastric stasis elicited by endotoxin is not mediated by CRF-R2 and CRF receptors are not involved in the basal regulation of fed or fasted pattern of gastric motility.
Keywords: CRF; CRF receptor; gastric emptying; stress; urocortin.
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
Similar articles
-
Peripheral urocortin delays gastric emptying: role of CRF receptor 2.Am J Physiol. 1999 Apr;276(4):G867-74. doi: 10.1152/ajpgi.1999.276.4.G867. Am J Physiol. 1999. PMID: 10198329
-
Corticotropin-releasing factor and the brain-gut motor response to stress.Can J Gastroenterol. 1999 Mar;13 Suppl A:18A-25A. doi: 10.1155/1999/375916. Can J Gastroenterol. 1999. PMID: 10202204 Review.
-
Differential actions of peripheral corticotropin-releasing factor (CRF), urocortin II, and urocortin III on gastric emptying and colonic transit in mice: role of CRF receptor subtypes 1 and 2.J Pharmacol Exp Ther. 2002 May;301(2):611-7. doi: 10.1124/jpet.301.2.611. J Pharmacol Exp Ther. 2002. PMID: 11961064
-
Intracerebroventricular urocortin 3 counteracts central acyl ghrelin-induced hyperphagic and gastroprokinetic effects via CRF receptor 2 in rats.Drug Des Devel Ther. 2016 Oct 3;10:3281-3290. doi: 10.2147/DDDT.S113195. eCollection 2016. Drug Des Devel Ther. 2016. PMID: 27757017 Free PMC article.
-
Role of peripheral CRF signalling pathways in stress-related alterations of gut motility and mucosal function.Neurogastroenterol Motil. 2004 Apr;16 Suppl 1:137-42. doi: 10.1111/j.1743-3150.2004.00490.x. Neurogastroenterol Motil. 2004. PMID: 15066020 Review.
Cited by
-
Central control of gastrointestinal motility.Curr Opin Endocrinol Diabetes Obes. 2019 Feb;26(1):11-16. doi: 10.1097/MED.0000000000000449. Curr Opin Endocrinol Diabetes Obes. 2019. PMID: 30418187 Free PMC article. Review.
-
Extra-adrenal glucocorticoid biosynthesis: implications for autoimmune and inflammatory disorders.Genes Immun. 2020 May;21(3):150-168. doi: 10.1038/s41435-020-0096-6. Epub 2020 Mar 23. Genes Immun. 2020. PMID: 32203088 Free PMC article. Review.
-
Therapeutic effects of mitoquinol during an acute heat stress challenge in growing barrows.J Anim Sci. 2024 Jan 3;102:skae161. doi: 10.1093/jas/skae161. J Anim Sci. 2024. PMID: 38860702 Free PMC article.
-
Assessing the Impact of the COVID-19 Pandemic on the Severity of Pediatric Inflammatory Bowel Disease Admissions and New Diagnoses.Crohns Colitis 360. 2023 Oct 25;5(4):otad062. doi: 10.1093/crocol/otad062. eCollection 2023 Oct. Crohns Colitis 360. 2023. PMID: 37941600 Free PMC article.
-
A neural circuit for gastric motility disorders driven by gastric dilation in mice.Front Neurosci. 2023 Feb 22;17:1069198. doi: 10.3389/fnins.2023.1069198. eCollection 2023. Front Neurosci. 2023. PMID: 36908796 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources