CCAT2: A novel oncogenic long non-coding RNA in human cancers

doi:10.1111/cpr.12342

Review

. 2017 Jun;50(3):e12342.

doi: 10.1111/cpr.12342. Epub 2017 Feb 28.

CCAT2: A novel oncogenic long non-coding RNA in human cancers

Yu Xin¹, Zheng Li², Heyi Zheng¹, Matthew T V Chan³, William Ka Kei Wu^{3

4}

Affiliations

¹ Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
² Department of Orthopedics Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
³ Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong, China.
⁴ State Key Laboratory of Digestive Disease, LKS Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.

PMID: 28244168
PMCID: PMC6529071
DOI: 10.1111/cpr.12342

Review

CCAT2: A novel oncogenic long non-coding RNA in human cancers

Yu Xin et al. Cell Prolif. 2017 Jun.

. 2017 Jun;50(3):e12342.

doi: 10.1111/cpr.12342. Epub 2017 Feb 28.

Authors

Yu Xin¹, Zheng Li², Heyi Zheng¹, Matthew T V Chan³, William Ka Kei Wu^{3

4}

Affiliations

¹ Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
² Department of Orthopedics Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
³ Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong, China.
⁴ State Key Laboratory of Digestive Disease, LKS Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.

PMID: 28244168
PMCID: PMC6529071
DOI: 10.1111/cpr.12342

Abstract

Colon cancer-associated transcript 2 (CCAT2) was originally identified as an oncogenic long non-coding RNA in colorectal cancer. Since its discovery, the oncogenic role of CCAT2 has been increasingly demonstrated in human cancers. In this connection, CCAT2 upregulation is frequently reported and very often associated with tumour progression and poor clinical outcomes. Functionally, knockdown of CCAT2 could induce cancer cell apoptosis and suppress cell proliferation and invasiveness, suggesting that CCAT2 might be a therapeutic target. The present review summarized current literature concerning the expression and functional role of CCAT2 in human malignancies.

Keywords: CCAT2; cancers; lncRNAs; long non-coding RNA.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing financial interests.

Cited by

Long non-coding RNAs in brain tumors: roles and potential as therapeutic targets.
Kim SH, Lim KH, Yang S, Joo JY. Kim SH, et al. J Hematol Oncol. 2021 May 12;14(1):77. doi: 10.1186/s13045-021-01088-0. J Hematol Oncol. 2021. PMID: 33980320 Free PMC article. Review.
The role of EMT-related lncRNA in the process of triple-negative breast cancer metastasis.
Zhang H, Wang J, Yin Y, Meng Q, Lyu Y. Zhang H, et al. Biosci Rep. 2021 Feb 26;41(2):BSR20203121. doi: 10.1042/BSR20203121. Biosci Rep. 2021. PMID: 33443534 Free PMC article. Review.
Long non-coding RNAs: crucial regulators of gastrointestinal cancer cell proliferation.
Chen J, Liu S, Hu X. Chen J, et al. Cell Death Discov. 2018 Apr 27;4:50. doi: 10.1038/s41420-018-0051-8. eCollection 2018. Cell Death Discov. 2018. PMID: 29736267 Free PMC article. Review.
Tectorigenin Inhibits Glycolysis-induced Cell Growth and Proliferation by Modulating LncRNA CCAT2/miR-145 Pathway in Colorectal Cancer.
Xing Y, Lin B, Liu B, Shao J, Jin Z. Xing Y, et al. Curr Cancer Drug Targets. 2024;24(10):1071-1079. doi: 10.2174/0115680096274757231219072003. Curr Cancer Drug Targets. 2024. PMID: 38243936 Free PMC article.
Gemini Curcumin Suppresses Gastric Cancer AGS Cell Proliferation Through Modulation of lncRNA CCAT2 and c-Myc Genes.
Jabbari N, Ghoran SH, Semsari H, Hussen BM, Babaei E. Jabbari N, et al. Turk J Pharm Sci. 2022 Jun 27;19(3):239-245. doi: 10.4274/tjps.galenos.2021.03502. Turk J Pharm Sci. 2022. PMID: 35773976 Free PMC article.

See all "Cited by" articles

References

1. Eddy SR. Non‐coding RNA genes and the modern RNA world. Nat Rev Genet. 2001;2:919‐929. doi:10.1038/35103511. - DOI - PubMed
1. Wilusz JE, Sunwoo H, Spector DL. Long noncoding RNAs: functional surprises from the RNA world. Genes Dev. 2009;23:1494‐1504. doi:10.1101/gad.1800909. - DOI - PMC - PubMed
1. Mercer TR, Dinger ME, Mattick JS. Long non‐coding RNAs: insights into functions. Nat Rev Genet. 2009;10:155‐159. doi:10.1038/nrg2521. - DOI - PubMed
1. Fatica A, Bozzoni I. Long non‐coding RNAs: new players in cell differentiation and development. Nat Rev Genet. 2014;15:7‐21. doi:10.1038/nrg3606. - DOI - PubMed
1. Schmitt AM, Chang HY. Long noncoding RNAs in cancer pathways. Cancer Cell. 2016;29:452‐463. doi:10.1016/j.ccell.2016.03.010. - DOI - PMC - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions

LinkOut - more resources

Full Text Sources
Other Literature Sources
- The Lens - Patent Citations Database
- scite Smart Citations

[1] Eddy SR. Non‐coding RNA genes and the modern RNA world. Nat Rev Genet. 2001;2:919‐929. doi:10.1038/35103511. - DOI - PubMed

[2] Eddy SR. Non‐coding RNA genes and the modern RNA world. Nat Rev Genet. 2001;2:919‐929. doi:10.1038/35103511. - DOI - PubMed

[3] Wilusz JE, Sunwoo H, Spector DL. Long noncoding RNAs: functional surprises from the RNA world. Genes Dev. 2009;23:1494‐1504. doi:10.1101/gad.1800909. - DOI - PMC - PubMed

[4] Wilusz JE, Sunwoo H, Spector DL. Long noncoding RNAs: functional surprises from the RNA world. Genes Dev. 2009;23:1494‐1504. doi:10.1101/gad.1800909. - DOI - PMC - PubMed

[5] Mercer TR, Dinger ME, Mattick JS. Long non‐coding RNAs: insights into functions. Nat Rev Genet. 2009;10:155‐159. doi:10.1038/nrg2521. - DOI - PubMed

[6] Mercer TR, Dinger ME, Mattick JS. Long non‐coding RNAs: insights into functions. Nat Rev Genet. 2009;10:155‐159. doi:10.1038/nrg2521. - DOI - PubMed

[7] Fatica A, Bozzoni I. Long non‐coding RNAs: new players in cell differentiation and development. Nat Rev Genet. 2014;15:7‐21. doi:10.1038/nrg3606. - DOI - PubMed

[8] Fatica A, Bozzoni I. Long non‐coding RNAs: new players in cell differentiation and development. Nat Rev Genet. 2014;15:7‐21. doi:10.1038/nrg3606. - DOI - PubMed

[9] Schmitt AM, Chang HY. Long noncoding RNAs in cancer pathways. Cancer Cell. 2016;29:452‐463. doi:10.1016/j.ccell.2016.03.010. - DOI - PMC - PubMed

[10] Schmitt AM, Chang HY. Long noncoding RNAs in cancer pathways. Cancer Cell. 2016;29:452‐463. doi:10.1016/j.ccell.2016.03.010. - DOI - PMC - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

CCAT2: A novel oncogenic long non-coding RNA in human cancers

Affiliations

CCAT2: A novel oncogenic long non-coding RNA in human cancers

Authors

Affiliations

Abstract

Conflict of interest statement

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Abstract

Conflict of interest statement

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Related information

LinkOut - more resources

Full Text Sources

Other Literature Sources