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Review
. 2017 Mar:54:74-86.
doi: 10.1016/j.ctrv.2017.01.008. Epub 2017 Feb 11.

The expanding role of immunotherapy

Juan Martin-Liberal  1 , María Ochoa de Olza  2 , Cinta Hierro  2 , Alena Gros  2 , Jordi Rodon  2 , Josep Tabernero  2
Affiliations
Review

The expanding role of immunotherapy

Juan Martin-Liberal et al. Cancer Treat Rev. 2017 Mar.

Abstract

The use of agents able to modulate the immune system to induce or potentiate its anti-tumour activity is not a new strategy in oncology. However, the development of new agents such as immune checkpoint inhibitors has achieved unprecedented efficacy results in a wide variety of tumours, dramatically changing the landscape of cancer treatment in recent years. Ipilimumab, nivolumab, pembrolizumab or atezolizumab are now standard of care options in several malignancies and new indications are being approved on a regular basis in different tumours. Moreover, there are many other novel immunotherapy strategies that are currently being assessed in clinical trials. Agonists of co-stimulatory signals, adoptive cell therapies, vaccines, virotherapy and others have raised interest as therapeutic options against cancer. In addition, many of these novel approaches are being developed both in monotherapy and as part of combinatory regimes in order to synergize their activity. The results from those studies will help to define the expanding role of immunotherapy in cancer treatment in a forthcoming future.

Keywords: Cell therapy; Checkpoint inhibitors; Co-stimulatory agonists; Combination; Vaccines; Virus.

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