The Dark Age(ing) of the Inflammasome

doi:10.1016/j.immuni.2017.02.009

Comment

. 2017 Feb 21;46(2):173-175.

doi: 10.1016/j.immuni.2017.02.009.

The Dark Age(ing) of the Inflammasome

Konrad Aden¹, Philip Rosenstiel²

Affiliations

¹ Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel, Rosalind-Franklin Str. 12, D-24105 Kiel, Germany.
² Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel, Rosalind-Franklin Str. 12, D-24105 Kiel, Germany. Electronic address: p.rosenstiel@mucosa.de.

PMID: 28228276
DOI: 10.1016/j.immuni.2017.02.009

Free article

Comment

The Dark Age(ing) of the Inflammasome

Konrad Aden et al. Immunity. 2017.

Free article

. 2017 Feb 21;46(2):173-175.

doi: 10.1016/j.immuni.2017.02.009.

Authors

Konrad Aden¹, Philip Rosenstiel²

Affiliations

¹ Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel, Rosalind-Franklin Str. 12, D-24105 Kiel, Germany.
² Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel, Rosalind-Franklin Str. 12, D-24105 Kiel, Germany. Electronic address: p.rosenstiel@mucosa.de.

PMID: 28228276
DOI: 10.1016/j.immuni.2017.02.009

Abstract

Mechanisms that contribute to healthy aging remain obscure. In a recent issue of Nature Medicine, Furman et al. (2017) describe that dietary caffeine inhibits the NLRC4 inflammasome, which is associated with disease-free aging.

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Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states.
Furman D, Chang J, Lartigue L, Bolen CR, Haddad F, Gaudilliere B, Ganio EA, Fragiadakis GK, Spitzer MH, Douchet I, Daburon S, Moreau JF, Nolan GP, Blanco P, Déchanet-Merville J, Dekker CL, Jojic V, Kuo CJ, Davis MM, Faustin B. Furman D, et al. Nat Med. 2017 Feb;23(2):174-184. doi: 10.1038/nm.4267. Epub 2017 Jan 16. Nat Med. 2017. PMID: 28092664 Free PMC article.

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The Dark Age(ing) of the Inflammasome

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The Dark Age(ing) of the Inflammasome

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