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. 2017 Feb 17;120(4):627-629.
doi: 10.1161/CIRCRESAHA.116.310058.

Cardiomyocyte Proliferation: Teaching an Old Dogma New Tricks

Katherine E Yutzey  1
Affiliations

Cardiomyocyte Proliferation: Teaching an Old Dogma New Tricks

Katherine E Yutzey. Circ Res. .

Abstract

The inability of the adult heart to repair or regenerate is manifested in prevalent morbidity and mortality related to myocardial infarction and heart failure. Cardiomyocyte proliferation, especially after myocardial infarction or in the context of heart failure, has been an area of intense research by many investigators for decades. As a researcher working in this area for the past 25 years, this has been an exciting time, requiring an open mind in leaving old accepted ideas behind and moving forward towards exploiting this new knowledge of cardiomyocyte plasticity.

Keywords: adult; animal; developmental biology; heart failure; regeneration.

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Figures

Figure
Figure
Regulatory mechanisms of cardiomyocyte proliferation and post-natal cell cycle arrest. Genetic activation of proliferative pathways or inhibition of arrest mechanisms can promote cardiomyocyte cell cycle activity and improve cardiac function after injury in adult mice.
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