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Review
. 2017 Apr;38(4):261-271.
doi: 10.1016/j.it.2017.01.003. Epub 2017 Feb 11.

Recent Insights into the Molecular Mechanisms Underlying Pyroptosis and Gasdermin Family Functions

Robin A Aglietti  1 , Erin C Dueber  2
Affiliations
Review

Recent Insights into the Molecular Mechanisms Underlying Pyroptosis and Gasdermin Family Functions

Robin A Aglietti et al. Trends Immunol. 2017 Apr.

Abstract

Pyroptosis is an inflammatory form of cell death that not only protects multicellular organisms from invading pathogenic bacteria and microbial infections, but can also lead to sepsis and lethal septic shock if overactivated. Here, we present an overview of recent developments within the pyroptosis field, beginning with the discovery of Gasdermin D (GSDMD) as a substrate of caspase-1 and caspase-11 upon detection of cytosolic lipopolysaccharide (LPS). Cleavage releases the N-terminal domain of GSDMD, causing it to form cytotoxic pores in the plasma membrane of cells. We further discuss the implications for the rest of the gasdermin (GSDM) family, which are emerging as mediators of programmed cell death in a variety of processes that regulate cellular differentiation and proliferation.

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