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Review
. 2017 Mar;33(3):208-219.
doi: 10.1016/j.tig.2017.01.003. Epub 2017 Feb 4.

Biogenesis and Function of Ago-Associated RNAs

Iben Daugaard  1 , Thomas Birkballe Hansen  2
Affiliations
Review

Biogenesis and Function of Ago-Associated RNAs

Iben Daugaard et al. Trends Genet. 2017 Mar.

Abstract

Numerous sophisticated high-throughput sequencing technologies have been developed over the past decade, and these have enabled the discovery of a diverse catalog of small non-coding (nc)RNA molecules that function as regulatory entities by associating with Argonaute (Ago) proteins. MicroRNAs (miRNAs) are currently the best-described class of post-transcriptional regulators that follow a specific biogenesis pathway characterized by Drosha/DGCR8 and Dicer processing. However, more exotic miRNA-like species that bypass particular steps of the canonical miRNA biogenesis pathway continue to emerge, with one of the most recent additions being the agotrons, which escape both Drosha/DGCR8- and Dicer-processing. We review here the current knowledge and most recent discoveries relating to alternative functions and biogenesis strategies for Ago-associated RNAs in mammals.

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