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Observational Study
. 2017 Feb;96(5):e5923.
doi: 10.1097/MD.0000000000005923.

Are gastric hyperplastic polyps an additional manifestation in celiac disease?: Results from a retrospective study

Maria Pina Dore  1 , Giovanni Mario Pes, Chiara Rocchi, Maria Francesca Loria, Sara Soro, Gabrio Bassotti
Affiliations
Observational Study

Are gastric hyperplastic polyps an additional manifestation in celiac disease?: Results from a retrospective study

Maria Pina Dore et al. Medicine (Baltimore). 2017 Feb.

Abstract

Gastric polyps are frequently reported in patients undergoing upper endoscopic procedures. In this retrospective study, the association between hyperplastic polyps and celiac disease in Northern Sardinia was estimated.Age, gender, body mass index, and medications taken in the 2 preceding months, including proton-pump inhibitors (PPIs), H2 receptor blockers (anti-H2), Helicobacter pylori status, endoscopic findings, and histology from charts of patients undergoing esophago-gastro-duodenoscopy were reviewed. Polyps were classified as hyperplastic, fundic gland, inflammatory, and adenomatous.3.7% (423/11379) patients had celiac disease. Prevalence of gastric polyps was 4.2% (3.8% among celiac vs 4.2% nonceliac patients). Inflammatory polyp was the most common histotype (55.8% and 56.2%) followed by fundic gland polyps (31.4% and 43.7%), hyperplastic (8.7% and 0%), and adenomas, in celiac and nonceliac patients, respectively. Fundic gland polyps were more common in PPI users (odds ratio: 4.06) than in nonusers (2.65, P = 0.001) among celiac and nonceliac patients. Age older than 50, female gender, esophago-gastro-duodenoscopy year, and PPI use were associated with the presence of polyps, whereas active H pylori infection was not.Gastric polyps were common in Sardinian patients undergoing esophago-gastro-duodenoscopy. However, the previously reported association between hyperplastic polyps and celiac disease was not confirmed in our study.

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Conflict of interest statement

The authors have no funding and conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Prevalence of gastric polyps in patients who underwent to esophago-gastro-duodenoscopy according to gender and age decades.
Figure 2
Figure 2
Representative images of hyperplastic (A), fundic gland (B), and inflammatory (C) polyps observed by esophago-gastro-duodenoscopy.
See this image and copyright information in PMC

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