Comment
doi: 10.1016/j.cell.2017.01.011.
Cryo-EM Captures the Dynamics of Ion Channel Opening
Affiliations
- PMID: 28129535
- DOI: 10.1016/j.cell.2017.01.011
Item in Clipboard
Comment
Cryo-EM Captures the Dynamics of Ion Channel Opening
Cell.
.
Free article
Abstract
In this issue of Cell, Hite and MacKinnon (2017) report the open conformation structure of Slo2.2, a neuronal Na+-activated K+ channel. More importantly, 3D classification of electron cryomicroscopy (cryo-EM) images allows visualization of the structural transition that occurs as the open probability of individual channels increases with added sodium.
Copyright © 2017 Elsevier Inc. All rights reserved.
Comment on
-
Structural Titration of Slo2.2, a Na+-Dependent K+ Channel.Cell. 2017 Jan 26;168(3):390-399.e11. doi: 10.1016/j.cell.2016.12.030. Epub 2017 Jan 19. Cell. 2017. PMID: 28111072 Free PMC article.
Similar articles
-
Structural Titration of Slo2.2, a Na+-Dependent K+ Channel.Cell. 2017 Jan 26;168(3):390-399.e11. doi: 10.1016/j.cell.2016.12.030. Epub 2017 Jan 19. Cell. 2017. PMID: 28111072 Free PMC article.
-
Structural basis of human Slo2.2 channel gating and modulation.Cell Rep. 2023 Aug 29;42(8):112858. doi: 10.1016/j.celrep.2023.112858. Epub 2023 Jul 25. Cell Rep. 2023. PMID: 37494189
-
Never at rest: insights into the conformational dynamics of ion channels from cryo-electron microscopy.J Physiol. 2018 Apr 1;596(7):1107-1119. doi: 10.1113/JP274888. Epub 2018 Mar 5. J Physiol. 2018. PMID: 29377132 Free PMC article. Review.
-
To Be or Not to Be an Ion Channel: Cryo-EM Structures Have a Say.Cells. 2023 Jul 17;12(14):1870. doi: 10.3390/cells12141870. Cells. 2023. PMID: 37508534 Free PMC article. Review.
-
Molecular mechanisms of Slo2 K+ channel closure.J Physiol. 2017 Apr 1;595(7):2321-2336. doi: 10.1113/JP273225. Epub 2016 Dec 2. J Physiol. 2017. PMID: 27682982 Free PMC article.
Cited by
-
New Structures and Gating of Voltage-Dependent Potassium (Kv) Channels and Their Relatives: A Multi-Domain and Dynamic Question.Int J Mol Sci. 2019 Jan 10;20(2):248. doi: 10.3390/ijms20020248. Int J Mol Sci. 2019. PMID: 30634573 Free PMC article. Review.
-
Rapid Enkephalin Delivery Using Exosomes to Promote Neurons Recovery in Ischemic Stroke by Inhibiting Neuronal p53/Caspase-3.Biomed Res Int. 2019 Mar 4;2019:4273290. doi: 10.1155/2019/4273290. eCollection 2019. Biomed Res Int. 2019. PMID: 30949500 Free PMC article.
-
Metal-Based Drug-DNA Interactions and Analytical Determination Methods.Molecules. 2024 Sep 13;29(18):4361. doi: 10.3390/molecules29184361. Molecules. 2024. PMID: 39339356 Free PMC article. Review.
-
Developments, applications, and prospects of cryo-electron microscopy.Protein Sci. 2020 Apr;29(4):872-882. doi: 10.1002/pro.3805. Epub 2019 Dec 26. Protein Sci. 2020. PMID: 31854478 Free PMC article. Review.
-
Cryo-EM in drug discovery: achievements, limitations and prospects.Nat Rev Drug Discov. 2018 Jul;17(7):471-492. doi: 10.1038/nrd.2018.77. Epub 2018 Jun 8. Nat Rev Drug Discov. 2018. PMID: 29880918 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
