Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016:2016:7931314.
doi: 10.1155/2016/7931314. Epub 2016 Dec 19.

The Role of Liuwei Dihuang Pills and Ginkgo Leaf Tablets in Treating Diabetic Complications

Yue Zhao  1 , Jiangyi Yu  1 , Jingshun Liu  1 , Xiaofei An  1
Affiliations

The Role of Liuwei Dihuang Pills and Ginkgo Leaf Tablets in Treating Diabetic Complications

Yue Zhao et al. Evid Based Complement Alternat Med. 2016.

Abstract

Objective. To observe the clinical prophylactic and therapeutic efficacy of Liuwei Dihuang Pills and Ginkgo Leaf Tablets for type 2 diabetic vascular complications. Methods. It was a randomized, double-blind and placebo-controlled clinical trial. 140 outpatients with type 2 diabetes were recruited and randomly divided into the treatment group and control group. The two groups were given basic therapy (management of blood sugar, blood pressure, etc.). Additionally, the treatment group was given Liuwei Dihuang Pills and Ginkgo Leaf Tablets, while the control group was given Liuwei Dihuang Pills and Ginkgo Leaf Tablets placebos. All subjects were followed up for consecutive 36 months and observed monthly. The clinical data as urinary microalbumin to urinary creatinine ratio (Umalb/cr), carotid intima-media thickness (IMT), diabetic nephropathy (DN) and diabetic retinopathy (DR) prevalence, cardiovascular and cerebrovascular events, blood glucose, and blood pressure were collected and analyzed statistically. Results. After 36-month treatment, the Umalb/cr level and DN and DR prevalence in treatment group were all significantly lower than control group (P < 0.05). However, the IMT level and the incidence of cardiovascular and cerebrovascular events were not significantly different between the two groups (P > 0.05). Conclusions. Liuwei Dihuang Pills and Ginkgo Leaf Tablets are beneficial to diabetic microvascular complications, while the efficacy to diabetic macrovascular complications needs more observations.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there is no conflict of interests.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. American Diabetes Association. 9. Microvascular complications and foot care. Diabetes Care. 2014;38, supplement 1:S58–S66. doi: 10.2337/dc15-s012. - DOI - PubMed
    1. Yau J. W. Y., Rogers S. L., Kawasaki R., et al. Global prevalence and major risk factors of diabetic retinopathy. Diabetes Care. 2012;35(3):556–564. doi: 10.2337/dc11-1909. - DOI - PMC - PubMed
    1. Javed S., Alam U., Malik R. A. Burning through the pain: treatments for diabetic neuropathy. Diabetes, Obesity and Metabolism. 2015;17(12):1115–1125. doi: 10.1111/dom.12535. - DOI - PubMed
    1. American Diabetes Association. 8. Cardiovascular disease and risk management. Diabetes Care. 2016;39(supplement 1):S60–S71. doi: 10.2337/dc16-S011. - DOI - PubMed
    1. Nathan D. M. Diabetes: advances in diagnosis and treatment. The Journal of the American Medical Association. 2015;314(10):1052–1062. doi: 10.1001/jama.2015.9536. - DOI - PubMed

LinkOut - more resources