The coupled and uncoupled mechanisms by which trans-acting factors regulate mRNA stability and translation
- PMID: 28039391
- DOI: 10.1093/jb/mvw086
The coupled and uncoupled mechanisms by which trans-acting factors regulate mRNA stability and translation
Abstract
In mammals, spatiotemporal control of protein synthesis plays a key role in the post-transcriptional regulation of gene expression during cell proliferation, development and differentiation and RNA-binding proteins (RBPs) and microRNAs (miRNAs) are required for this phenomenon. RBPs and miRNAs control the levels of mRNA protein products by regulating mRNA stability and translation. Recent studies have shown that RBPs and miRNAs simultaneously regulate mRNA stability and translation, and that the differential functions of RBPs and miRNAs are dependent on their interaction partners. Here, we summarize the coupled- and uncoupled mechanisms by which trans-acting factors regulate mRNA stability and translation.
Keywords: AU-rich element; RNA-binding protein; deadenylation; microRNA; translation.
© The Authors 2016. Published by Oxford University Press on behalf of the Japanese Biochemical Society. All rights reserved.
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