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Comment
. 2016 Dec 13;113(50):14176-14178.
doi: 10.1073/pnas.1617402113. Epub 2016 Nov 30.

Two for the price of one: RNA modification enzymes as chaperones

Sandra L Wolin  1   2
Affiliations
Comment

Two for the price of one: RNA modification enzymes as chaperones

Sandra L Wolin. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Model for TruB function. Upon folding of a nascent tRNA into the cloverleaf structure (A), TruB binds the T arm (T) and reversibly and repeatedly disrupts tertiary interactions between the T and D loops, giving the tRNA additional chances to complete folding (B and C). After catalyzing Ψ55 formation (D), TruB dissociates (E). AC, anticodon arm.
See this image and copyright information in PMC

Comment on

  • RNA modification enzyme TruB is a tRNA chaperone.
    Keffer-Wilkes LC, Veerareddygari GR, Kothe U. Keffer-Wilkes LC, et al. Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):14306-14311. doi: 10.1073/pnas.1607512113. Epub 2016 Nov 14. Proc Natl Acad Sci U S A. 2016. PMID: 27849601 Free PMC article.

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References

    1. Machnicka MA, et al. MODOMICS: A database of RNA modification pathways--2013 update. Nucleic Acids Res. 2013;41(Database issue):D262–D267. - PMC - PubMed
    1. Ge J, Yu YT. RNA pseudouridylation: New insights into an old modification. Trends Biochem Sci. 2013;38(4):210–218. - PMC - PubMed
    1. Persson BC, Gustafsson C, Berg DE, Björk GR. The gene for a tRNA modifying enzyme, m5U54-methyltransferase, is essential for viability in Escherichia coli. Proc Natl Acad Sci USA. 1992;89(9):3995–3998. - PMC - PubMed
    1. Gutgsell N, et al. Deletion of the Escherichia coli pseudouridine synthase gene truB blocks formation of pseudouridine 55 in tRNA in vivo, does not affect exponential growth, but confers a strong selective disadvantage in competition with wild-type cells. RNA. 2000;6(12):1870–1881. - PMC - PubMed
    1. Johansson MJ, Byström AS. Dual function of the tRNA(m(5)U54)methyltransferase in tRNA maturation. RNA. 2002;8(3):324–335. - PMC - PubMed

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