Evolution of KRAB-containing zinc finger proteins and their roles in species evolution
- PMID: 27867147
- DOI: 10.16288/j.yczz.16-056
Evolution of KRAB-containing zinc finger proteins and their roles in species evolution
Abstract
The C2H2 zinc finger protein family, one of the largest families of transcription factor/transcriptional regulator in mammal, arose from a small ancestral group of eukaryotic zinc finger transcription factors through many repeated gene duplications accompanied by functional divergence. As the biggest subfamily of C2H2 zinc finger protein family, Kruppel-associated box-containing zinc finger proteins (KRAB-ZFPs) appeared at the period oftetrapod, expand rapidly along with species evolution, and take about 60% of the total C2H2 zinc finger proteins in human. During species evolution, the DNA binding ability of KRAB-ZFPs is changed while the KRAB-ZFPs-mediate transcriptional repression ability maintains stable under the evolution pressure. Moreover, multiple KRAB-ZFPs function synergistically with KAP1 on transcriptional silencing of retroelements, and the coevolution between KRAB-ZFPs and target retrotransposons restrict the jumping ability of the retroelements. In this review, we summarize the roles of KRAB-ZFPs duplication, the flexibility of zinc finger structure, transcriptional repression of KRAB-ZFPs/KAP1 and retroelement "jump" in promoting the divergence in regulatory network, stable genome change and species evolution, in order to reveal the characters and functions of KRAB-ZFPs in driving species evolution stably.
Similar articles
-
KRAB-zinc finger proteins and KAP1 can mediate long-range transcriptional repression through heterochromatin spreading.PLoS Genet. 2010 Mar 5;6(3):e1000869. doi: 10.1371/journal.pgen.1000869. PLoS Genet. 2010. PMID: 20221260 Free PMC article.
-
Spotting the enemy within: Targeted silencing of foreign DNA in mammalian genomes by the Krüppel-associated box zinc finger protein family.Mob DNA. 2015 Oct 2;6:17. doi: 10.1186/s13100-015-0050-8. eCollection 2015. Mob DNA. 2015. PMID: 26435754 Free PMC article. Review.
-
The Role of KRAB-ZFPs in Transposable Element Repression and Mammalian Evolution.Trends Genet. 2017 Nov;33(11):871-881. doi: 10.1016/j.tig.2017.08.006. Epub 2017 Sep 19. Trends Genet. 2017. PMID: 28935117 Free PMC article. Review.
-
KRAB zinc finger proteins.Development. 2017 Aug 1;144(15):2719-2729. doi: 10.1242/dev.132605. Development. 2017. PMID: 28765213 Free PMC article. Review.
-
The signaling pathways regulated by KRAB zinc-finger proteins in cancer.Biochim Biophys Acta Rev Cancer. 2022 May;1877(3):188731. doi: 10.1016/j.bbcan.2022.188731. Epub 2022 Apr 25. Biochim Biophys Acta Rev Cancer. 2022. PMID: 35483489 Review.
Cited by
-
Transcriptome analysis provides new insights into cold adaptation of corsac fox (Vulpes Corsac).Ecol Evol. 2022 Apr 19;12(4):e8866. doi: 10.1002/ece3.8866. eCollection 2022 Apr. Ecol Evol. 2022. PMID: 35462974 Free PMC article.
-
Exploration of the regulatory relationship between KRAB-Zfp clusters and their target transposable elements via a gene editing strategy at the cluster specific linker-associated sequences by CRISPR-Cas9.Mob DNA. 2022 Nov 10;13(1):25. doi: 10.1186/s13100-022-00279-x. Mob DNA. 2022. PMID: 36357895 Free PMC article.
-
Broadly active zinc finger protein-guided transcriptional activation of HIV-1.Mol Ther Methods Clin Dev. 2020 Oct 27;20:18-29. doi: 10.1016/j.omtm.2020.10.018. eCollection 2021 Mar 12. Mol Ther Methods Clin Dev. 2020. PMID: 33335944 Free PMC article.
-
Overexpression of zinc-finger protein 677 inhibits proliferation and invasion by and induces apoptosis in clear cell renal cell carcinoma.Bioengineered. 2022 Mar;13(3):5292-5304. doi: 10.1080/21655979.2022.2038891. Bioengineered. 2022. PMID: 35164660 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Research Materials
Miscellaneous