Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Nov 17;167(5):1163-1166.
doi: 10.1016/j.cell.2016.10.054.

The Ties That Bind: Mapping the Dynamic Enhancer-Promoter Interactome

Cailyn H Spurrell  1 , Diane E Dickel  1 , Axel Visel  2
Affiliations
Review

The Ties That Bind: Mapping the Dynamic Enhancer-Promoter Interactome

Cailyn H Spurrell et al. Cell. .

Abstract

Coupling chromosome conformation capture to molecular enrichment for promoter-containing DNA fragments enables the systematic mapping of interactions between individual distal regulatory sequences and their target genes. In this Minireview, we describe recent progress in the application of this technique and related complementary approaches to gain insight into the lineage- and cell-type-specific dynamics of interactions between regulators and gene promoters.

PubMed Disclaimer

Figures

Figure 1
Figure 1. Lineage-specific interactions of promoters with non-coding regulatory sequences
Left: Javierre et al. (2016) used promoter capture Hi-C (PCHi-C) to systematically map interactions between promoters and promoter-interacting regions (PIRs) across 17 primary human hematopoietic cell types (left, 10 representative examples shown). Right: Comparison of PIR-promoter interactions across cell types reveals that some interactions are invariant across all cell types examined, while others are specific to major lineages or individual cell types. Importantly, some promoters interact with different sets of PIRs depending on cell type and, vice versa, some PIRs interact with different sets of promoters in a cell-type-specific manner.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Altshuler D, Lander E, Ambrogio L. Nature. 2010;476:1061–1073. - PubMed
    1. Anthony D, Schmitt, Hu Ming, Jung Inkyung, Xu Zheng, Qiu Yunjiang, Tan Catherine L., Li Yun, Barr Cathy L., B.R. Cell. 2016 - PMC - PubMed
    1. Bae J-B. Genomics Inform. 2013;11:7–14. - PMC - PubMed
    1. Javierre Biola M., Burren Oliver S., Wilder Steven P., Kreuzhuber R, Hill Steven M., Sewitz Sven, Cairns Jonathan, Wingett S,W, Várnai Csilla, Thiecke Michiel J., Burden Frances, Farrow S, Cutler Antony J., Rehnstrom Karola, Downes Kate, Grassi L, Kostadima Myrto, Freire-Pritchett1 Paula, Fan Wang T, BLUEPRINT Consortium. Stunnenberg Hendrik G., Todd John A., Zerbino DR, Stegle Oliver, Ouwehand Willem H., Frontini Mattia, C., Wallace MS, P.F. Cell. 2016 - PubMed
    1. Breeze Charles E., Paul Dirk S., van Dongen Jenny, Butcher Lee M., Ambrose John C., Barrett James E., Lowe Robert, Rakyan Vardhman K., Iotchkova Valentina, Frontini Mattia, Downes Kate, Ouwehand Willem H., Laperle Jonathan, Jacques Pierre-Étienne, Guilla, S.B. Cell Reports. 2016 - PMC - PubMed

Publication types

LinkOut - more resources