Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1989 Feb;86(4):1168-72.
doi: 10.1073/pnas.86.4.1168.

v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas

W Y Langdon  1 , J W Hartley, S P Klinken, S K Ruscetti, H C Morse 3rd
Affiliations

v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas

W Y Langdon et al. Proc Natl Acad Sci U S A. 1989 Feb.

Abstract

Cas NS-1 is an acutely transforming murine retrovirus that induces pre-B and pro-B cell lymphomas. Molecular cloning showed it was generated from the ecotropic Cas-Br-M virus by sequential recombinations with endogenous retroviral sequences and a cellular oncogene. The oncogene sequence shows no homology with known oncogenes but some similarity to the yeast transcriptional activator GCN4. A 100-kDa gag-cbl fusion protein, with no detectable kinase activity, is responsible for the cellular transformation. The cellular homologue of v-cbl, present in mouse and human DNA, is expressed in a range of hemopoietic lineages.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 - PubMed
    1. Proc Natl Acad Sci U S A. 1977 Feb;74(2):789-92 - PubMed
    1. J Virol. 1979 Jun;30(3):787-98 - PubMed
    1. J Virol. 1979 Sep;31(3):752-60 - PubMed
    1. Nature. 1980 Feb 28;283(5750):826-31 - PubMed

Publication types

Substances

Associated data